247 The medicinal and antitumour mushroom, agaricus blazei murill, activates NF-KB via TLR2 in monocytic cells and induces expression of cell surface markers and production of cytokines in human monocyte-derived dendritic cells (MDDC) in vitro

Hetland, Geir; Tryggestad, Anne Merete Aaland; Espevik, Terje; Ryan, Liv; Tangen, Jon‐Magnus; Johnson, Egil; Kvalheim, Gunnar

doi:10.1016/s1359-6349(10)71054-5

Cited by 2 publications

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“…In fact, it was a surprise when it recently was revealed that the β‐glucan content of Andosan™ was very low, probably due to its source being mycelia and not fruiting body 74 . Nevertheless, this mixed mushroom extract did stimulate TLR2 in monocytic cells 75 . Such AbM stimulation is shown to promote differentiation of M2 to M1 cells and induce a potent antitumour effect 76 .…”

Section: Mechanism Of Action—immunomodulation and Defence At The Mucosamentioning

confidence: 99%

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Can medicinal mushrooms have prophylactic or therapeutic effect against COVID‐19 and its pneumonic superinfection and complicating inflammation?

et al. 2020

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Medicinal mushrooms have documented effects against different diseases, including infections and inflammatory disorders. The related Basidiomycota Agaricus blaz ei Murill (AbM), Hericium erinaceus (HE), and Grifola frondosa (GF) have been shown to exert antimicrobial activity against viral agents, Gram‐positive and Gram‐negative bacteria, and parasites in vitro and in vivo. Since the mechanism is immunomodulatory and not antibiotical, the mushrooms should be active against multi‐drug resistant microbes as well. Moreover, since these Basidiomycota also have anti‐inflammatory properties, they may be suited for treatment of the severe lung inflammation that often follows COVID‐19 infection. An AbM‐based mushroom extract (Andosan™), also containing HE and GF, has been shown to significantly reduce bacteraemia and increase survival in mice with pneumococcal sepsis, and to improve symptoms and quality of life in IBD patients via an anti‐inflammatory effect. Hence, such mushroom extracts could have prophylactic or therapeutic effect against the pneumonic superinfection and severe lung inflammation that often complicates COVID‐19 infection. Here, we review antimicrobial and anti‐inflammatory properties of AbM, HE and GF mushrooms, which could be used for the battle against COVID‐19.

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Section: Mechanism Of Action—immunomodulation and Defence At The Mucosamentioning

confidence: 99%

“…74 Nevertheless, this mixed mushroom extract did stimulate TLR2 in monocytic cells. 75 Such AbM stimulation is shown to promote differentiation of M2 to M1 cells and induce a potent antitumour effect. 76 AbM also stimulates the expression of NKG2D/NCR cell surface receptors on NK cells.…”

Section: Immunomodulation and Defence At The Mucosamentioning

confidence: 99%

Can medicinal mushrooms have prophylactic or therapeutic effect against COVID‐19 and its pneumonic superinfection and complicating inflammation?

et al. 2020

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“…An increased production of cytokines and chemokines was demonstrated after incubation with AndoSan in cultures with human monocytes, umbilical vein endothelial cells, and monocyte derived dendritic cells (MDDC) [ 14 , 15 ]. Incubation with AndoSan in MDDC cultures was shown to increase the expression of cell surface markers associated with activation and antigen presentation [ 16 , 17 ]. Furthermore, in an mRNA assay on monocytic cells incubated with AndoSan, there was an upregulation of genes related to immune function, in particular in genes connected with proinflammatory cytokines [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effects of theAgaricus blazeiMurrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study

Tangen

Tierens

Caers

et al. 2015

BioMed Research International

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Forty patients with multiple myeloma scheduled to undergo high dose chemotherapy with autologous stem cell support were randomized in a double blinded fashion to receive adjuvant treatment with the mushroom extract AndoSan, containing 82% of Agaricus blazei Murrill (19 patients) or placebo (21 patients). Intake of the study product started on the day of stem cell mobilizing chemotherapy and continued until the end of aplasia after high dose chemotherapy, a period of about seven weeks. Thirty-three patients were evaluable for all study endpoints, while all 40 included patients were evaluable for survival endpoints. In the leukapheresis product harvested after stem cell mobilisation, increased percentages of Treg cells and plasmacytoid dendritic cells were found in patients receiving AndoSan. Also, in this group, a significant increase of serum levels of IL-1ra, IL-5, and IL-7 at the end of treatment was found. Whole genome microarray showed increased expression of immunoglobulin genes, Killer Immunoglobulin Receptor (KIR) genes, and HLA genes in the Agaricus group. Furthermore, AndoSan displayed a concentration dependent antiproliferative effect on mouse myeloma cells in vitro. There were no statistically significant differences in treatment response, overall survival, and time to new treatment. The study was registered with Clinicaltrials.gov NCT00970021.

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247 The medicinal and antitumour mushroom, agaricus blazei murill, activates NF-KB via TLR2 in monocytic cells and induces expression of cell surface markers and production of cytokines in human monocyte-derived dendritic cells (MDDC) in vitro

Cited by 2 publications

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Can medicinal mushrooms have prophylactic or therapeutic effect against COVID‐19 and its pneumonic superinfection and complicating inflammation?

Can medicinal mushrooms have prophylactic or therapeutic effect against COVID‐19 and its pneumonic superinfection and complicating inflammation?

Immunomodulatory Effects of theAgaricus blazeiMurrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study

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