249 Airway responsiveness to methacholine following inhalation of nebulised hypertonic saline in bronchial asthma

O'Hickey, S P; Arm, JP; Rees, P. J.; Lee, Tae Hoon

doi:10.1016/0091-6749(88)90484-8

Cited by 3 publications

(4 citation statements)

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“…Four to six measurements were recorded at each time point and the mean was calculated. The coefficient of variation of PD 35 values for two hypertonic saline challenges which were separated by two weeks is 17% in our laboratory [11).…”

Section: Hypertonic Saline Challenge and Measurements Of Specific Air...mentioning

confidence: 81%

“…Specific airways conductance (sGaw) was used a~ a measurement of large airways calibre [14). Using this method we have previously demonstrated that airways responsiveness to hyperosmolar saline challenge is highly reproducible [11].…”

Section: Discussionmentioning

confidence: 99%

“…HS challenges were performed using a DeVilbiss 65 ultrasonic nebuliser as previously described [11]. The subjects inhaled doubling volumes of HS aerosol commencing at 5 I untillhere was a > 35% fall in specific airways conductance (sGaw) or until a maximum cumulative dose of 315 I of HS aerosol had been given.…”

Section: Hypertonic Saline Challenge and Measurements Of Specific Air...mentioning

confidence: 99%

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Airway responsiveness to adenosine 5' monophosphate following inhalation of hypertonic saline

O'Hickey¹,

Rees²,

Lee³

1989

Eur Respir J

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We wished to determine whether the refractory period after hypertonic saline (HS) challenge is due to mast cell mediator depletion. Therefore, the airway responsiveness to adenosine 5' monophosphate (AMP), which induces bronchoconstriction via mast cell histamine release, was determined after the inhalation of HS aerosol. Nine asthmatic subjects attended the laboratory on three occasions. On day 1 HS challenge was performed followed one hour later by a second HS challenge. On day 2 an AMP challenge was performed. On day 3 an HS challenge was performed followed one hour later by an AMP challenge. Airway responsiveness (PD35 sGaw) to an initial HS challenge ranged from 12 to 315 l of aerosol (mean 47 l). Airway responsiveness to a second HS challenge ranged from 8 to 800 l (mean 102 l p = 0.035, n = 9). Airway responsiveness to AMP increased from 0.44 to 14.0 mumol (mean 2.37 mumol) at baseline to 0.3 to 15.5 (mean 1.3 mumol) (p = 0.05) after HS challenge. There was a linear correlation between baseline AMP responsiveness and baseline HS responsiveness (r = 0.911, p = 0.001). There was no correlation between the degree of refractoriness and the change in AMP responsiveness (r = 0.1, p = 0.9). Thus airway responsiveness to AMP increased significantly after inhalation of HS aerosol and this increase was independent of refractory behaviour. Our results suggest that the refractory period to HS is not due to mediator depletion.

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Section: Hypertonic Saline Challenge and Measurements Of Specific Air...mentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Hypertonic Saline Challenge and Measurements Of Specific Air...mentioning

confidence: 99%

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Airway responsiveness to adenosine 5' monophosphate following inhalation of hypertonic saline

O'Hickey¹,

Rees²,

Lee³

1989

Eur Respir J

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“…as a positive response (a wheal of~ mm greater than Previous studies have suggested that refractory behaviour to hypertonic saline challenge cannot be attributed to protective catecholamines [3]. a reduction of nonspecific airways responsiveness after the initial challenge [4], or mediator depletion of airway mast cells [3,5]. Refractory behaviour also occurs after exercise-induced asthma [6}, ultrasonically nebulized distilled water (UNDW) challenge [1,7], and dry-air hyperventilation [8].…”

mentioning

confidence: 99%

The effects of indomethacin on the refractory period to hypertonic saline-induced bronchoconstriction

Hawksworth

O'Hickey²,

Lee³

1992

Eur Respir J

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The purpose of this study was to determine the effect of pretreatment with indomethacin on the refractory period to hypertonic saline-induced bronchoconstriction. In a double-blind, placebo-controlled, randomized trial nine asthmatic subjects underwent two hypertonic saline challenges, 60 min apart, on a control day and after premedication with indomethacin 50 mg or matching placebo, twice daily for three days. Premedication with indomethacin did not change airway responsiveness to the initial hypertonic saline challenge. The mean maximal % fall in specific airway conductance (sGaw) was 40.3, 44.1 and 47.6% on the control, placebo and indomethacin days, respectively. Subjects were significantly less responsive to the second hypertonic challenge as compared to the initial challenge on all three study days. There was a variable effect of indomethacin pretreatment on the refractory period. Five subjects lost their refractory period after indomethacin, when the variability of the test was taken into account. This suggests that there may be contributory mechanisms to the refractory period other than the release of protective prostanoid metabolites.

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Cross refractoriness between bradykinin and hypertonic saline challenges in asthma

Rajakulasingam¹,

Makker²,

Howarth³

et al. 1995

Journal of Allergy and Clinical Immunology

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249 Airway responsiveness to methacholine following inhalation of nebulised hypertonic saline in bronchial asthma

Cited by 3 publications

References 0 publications

Airway responsiveness to adenosine 5' monophosphate following inhalation of hypertonic saline

Airway responsiveness to adenosine 5' monophosphate following inhalation of hypertonic saline

The effects of indomethacin on the refractory period to hypertonic saline-induced bronchoconstriction

Cross refractoriness between bradykinin and hypertonic saline challenges in asthma

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