249 Different prevalence of sensitization against galactose--1,3-galactose between Shimane and Miyagi in Japan

Abstract

The red meat allergy caused by tick bites are increasing worldwide. It is known that IgE epitope of major red meat allergens is galactose-1,3-galactose (a-Gal). Thus, the patients with red meat allergy have a high risk to develop anaphylaxis to taking cetuximab that chimeratype monoclonal antineoplastic drug, because it also contains a-Gal, and its cross-reaction. The a-Gal specific IgE (sIgE) test by CAP-fluoro-enzyme immunoassay (FEIA) is one of the most sensitive examination to identify the patients with red meat allergy. In this study, we aimed to evaluate the prevalence of sensitization against a-Gal in Shimane prefecture that the endemic area of Japanese spotted fever and Miyagi prefecture that the area with lowincidence of Japanese spotted fever. We enrolled 200 patients from Shimane University Hospital and Tohoku University Hospital, and those patients had examined without complaining red meat allergy. a-Gal and beef sIgE tests were determined by the CAP-FEIA. The IgE reactivity to cetuximab was assessed by immunoblotting. From 100 subjects in Shimane, four were positive with beef-sIgE, and seven were positive with a-Gal-sIgE and five of them found to have IgE against cetuximab by immunoblotting. Whereas, 100 subjects from Miyagi, one was positive with a-Gal and four were positive with beef sIgE tests, but no one of subjects with positive either a-Gal or beef sIgE was not found to have IgE against cetuximab by immunoblotting. The result revealed that prevalence of sensitization against a-Gal is 7% in Shimane and 1% in Miyagi. However, they had no history of red meat allergy. The cetuximab-sIgE was detected 5% in Shimane, whereas it was 0% in Miyagi. These results indicate that prevalence of sensitization against a-Gal is different among the areas in Japan. Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma, and some studies have shown that the incidence rate (IR) and prognosis varies between race/ethnic (R/E) groups. This study aims to investigate whether R/E disparities in MF IR have changed from 2000 to 2014 using the Health Disparities Calculator (HD*calc) produced by the SEER Program. SEER data, excluding Alaska Native and Louisiana registries, from 2000 to 2014 were used to estimate age-adjusted IR of MF by gender and R/E group. R/E categories were limited to White, Black, Asian/Pacific Islander, American Indian, or Hispanic. IRs were inputted into HD*calc to generate the range difference (RD), a measure of disparity. RD is calculated as the difference in IR of MF between the R/E group with the highest IR and lowest IR (a RD of 0 indicates no disparity exists). RD measures the absolute range of IR across all R/E groups. TheBlack non-Hispanic R/E group had the highest age-adjusted IR of MF, ranging from 0.53 to 1.30 cases per 100,000. Moreover, RD increased for males: 0.79 to 1.06, a 34.2% change; and for females: 0.77 to 1.02, a 31.9% change. These nation-wide findings indicate that R/E disparities in IR for MF have increased using the range difference measure, particularly f...