25-hydroxyvitamin D-1α-hydroxylase in normal and malignant colon tissue

Tangpricha, Vin; Flanagan, John N.; Whitlatch, Lyman W.; Tseng, Chi Chuan; Chen, Thomas; Holt, Peter R.; Lipkin, Martin; Holick, Michael F.

doi:10.1016/s0140-6736(00)04831-5

Cited by 240 publications

(158 citation statements)

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“…This active hormonal form of vitamin D has the potent anti-cancer properties. It has been discovered that various types of normal and cancerous tissues, including prostate cells [128], colon tissue [129], breast, ovarian and cervical tissue [130], pancreatic tissue [131] and a lung cancer cell line [132] all have the ability to convert the major circulating form of vitamin D, 25(OH)D, into the active hormonal form, 1,25(OH) 2 D. So, there is a local mechanism in many tissues of the body for converting the form of vitamin D in the body that is elevated by sunshine exposure into a hormone that has anticancer activity.…”

Section: Reviewmentioning

confidence: 99%

Nutrition and cancer: A review of the evidence for an anti-cancer diet

Donaldson¹

2004

Nutr J

564

344

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It has been estimated that 30–40 percent of all cancers can be prevented by lifestyle and dietary measures alone. Obesity, nutrient sparse foods such as concentrated sugars and refined flour products that contribute to impaired glucose metabolism (which leads to diabetes), low fiber intake, consumption of red meat, and imbalance of omega 3 and omega 6 fats all contribute to excess cancer risk. Intake of flax seed, especially its lignan fraction, and abundant portions of fruits and vegetables will lower cancer risk. Allium and cruciferous vegetables are especially beneficial, with broccoli sprouts being the densest source of sulforophane. Protective elements in a cancer prevention diet include selenium, folic acid, vitamin B-12, vitamin D, chlorophyll, and antioxidants such as the carotenoids (α-carotene, β-carotene, lycopene, lutein, cryptoxanthin). Ascorbic acid has limited benefits orally, but could be very beneficial intravenously. Supplementary use of oral digestive enzymes and probiotics also has merit as anticancer dietary measures. When a diet is compiled according to the guidelines here it is likely that there would be at least a 60–70 percent decrease in breast, colorectal, and prostate cancers, and even a 40–50 percent decrease in lung cancer, along with similar reductions in cancers at other sites. Such a diet would be conducive to preventing cancer and would favor recovery from cancer as well.

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Section: Reviewmentioning

confidence: 99%

Nutrition and cancer: A review of the evidence for an anti-cancer diet

Donaldson¹

2004

Nutr J

564

344

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“…Previous studies of P450 expression and activity in colon cancer have studied only a limited number of P450s (30,(34)(35)(36). CYP3A immunoreactivity (30) and CYP3A-associated activity (34) have both been detected in colon cancer.…”

Section: Cytochrome P450 In Colorectal Cancermentioning

confidence: 99%

Cytochrome P450 Profile of Colorectal Cancer: Identification of Markers of Prognosis

Kumarakulasingham

Rooney

Dundas

et al. 2005

Clinical Cancer Research

152

143

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Purpose: The cytochromes P450 (P450) are a multigene family of enzymes with a central role in the oxidative metabolism of a wide range of xenobiotics, including anticancer drugs, carcinogens, and endogenous compounds. The purpose of this study was to define the P450 profile of colorectal cancer and establish the prognostic significance of expression of individual P450s in colorectal cancer. Experimental Design: Immunohistochemistry for a panel of 23 P450s was done on a colorectal cancer tissue microarray consisting of 264 primary colorectal cancers, 91lymph node metastasis, and 10 normal colorectal samples. The intensity of immunoreactivity in each sample was established by light microscopy. Results: The most frequently expressed form of P450 in normal colon was CYP3A4. In primary colorectal cancer, several P450s (CYP1B1, CYP2S1, CYP2U1, CYP3A5, and CYP51) were present at a significantly higher level of intensity compared with normal colon. P450 expression was also detected in lymph node metastasis and the presence of several P450s (CYP1B1, CYP2A/2B, CYP2F1, CYP4V2, and CYP39) in the lymph node metastasis strongly correlated with their presence in corresponding primary tumors. The presence of strong CYP51 (log-rank = 12.11, P = 0.0005) or strong CYP2S1 (log-rank = 6.72, P = 0.0095) immunoreactivity were associated with poor prognosis. CYP51 was also an independent marker of prognosis (P = 0.009). Conclusions: The expression of individual P450s has been established in colorectal cancer. Several P450s show increased expression in colorectal cancer. High expression of CYP51or CYP2S1 were associated with poor prognosis and CYP51is an independent marker of prognosis.

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“…Extrarenal activity of 25(OH)D 3 -1a-hydroxylase has been reported in various cell types including macrophages, keratinocytes, prostate and colon cancer cells. [25][26][27][28][29] The aim of this study was to analyze the expression of the vitamin D system in BCCs. We addressed the following questions: (i) Do BCCs express the main enzymes involved in the formation or metabolism of calcitriol, indicating that endogenous synthesis or metabolism of vitamin D metabolites may be involved in growth regulation of BCCs?…”

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confidence: 99%