25‐hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus

Wu, Peggy; Rhew, Elisa Y.; Dyer, Alan R.; Dunlop, Dorothy D.; Langman, Craig B.; Price, Heather E.; Sutton-Tyrrell, Kim; McPherson, David D.; Edmundowicz, Daniel; Kondos, George T.; Ramsey‐Goldman, Rosalind

doi:10.1002/art.24785

Cited by 105 publications

(116 citation statements)

References 48 publications

(74 reference statements)

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“…Poor vitamin D intake and low blood levels of vitamin D metabolites are associated with increased incidence and severity of several autoimmune diseases involving the T-helper type 1 lymphocyte [18], including multiple sclerosis [19], rheumatoid arthritis [20], type I diabetes [21], systemic lupus erythematosus [22] and psoriasis [23]. Lower levels of vitamin D, adjusted for body mass index, are also associated with increased risk of hypertension, myocardial infarction, and death as a result of cardiovascular disease [24].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency and Pseudofractures in Child-Bearing Egyptian Women: Successful Medical Treatment Helps to Avoid Fractures and Surgical Interference

El-Sagheer¹,

Soliman²,

Abdulla³

et al. 2016

OJEMD

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Background: Recent evidence for the effects of vitamin D and recognition of the high prevalence of its deficiency has increased the interest in it. Vitamin D-sub nutrition may contribute to the risk of a wide range of disorders. Methods: The females in the child-bearing period attending the endocrinology and orthopedic out-patient clinics complaining of pain and/or tenderness at the groin were evaluated. Patients with chronic metabolic or skeletal illness, primary hyperparathyroidism, and patients receiving drugs that interfere with bone mineral metabolisms were excluded. One hundred accepted and consented to participation in the study. All the participants were subjected to full history taking, clinical evaluation, laboratory investigations including serum Ca, Ph, PTH, ALP, TSH, F T4, F T3, Cortisol level, and 25(OH)D level. Plain X-ray was done for the regions of bony tenderness. The subjects were divided into 2 groups based on the presence or absence of pseudo-fractures (looser zones). They were treated and followed up till normalization of the laboratory parameters and healing of the looser zones. Results: The mean age for patients was 30.45 ± 5.8, their mean 25(OH) vitamin D level was 14.7 ± 5.9 ng/ml, the mean PTH was 195.7 ± 162.6, and looser zones were evident in the X-rays of 34 patients 184sun exposure, low dairy products consumption, and lack of vitamin D supplementation. Successful medical treatment may be helpful to satisfy the patient, avoid true fracture and further major surgical treatments.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Deficiency and Pseudofractures in Child-Bearing Egyptian Women: Successful Medical Treatment Helps to Avoid Fractures and Surgical Interference

El-Sagheer¹,

Soliman²,

Abdulla³

et al. 2016

OJEMD

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“…However, after further adjustment for BMI, the relationship was no longer significant. This clearly demonstrates the need to control for all factors that will impact on vitamin D status in the analysis and may potentially explain why others have not found similar results (17,18,25,26) . A Brazilian cohort of SLE patients sub-divided based on disease activity found serum 25(OH)D to be significantly inversely related to SLEDAI (P = 0 .…”

Section: Seasonal Variation and Disease Activity In Systemic Lupus Ermentioning

confidence: 90%

“…An additional study of female SLE patients from the Chicago Lupus Database reported a significant inverse relationship between serum 25(OH)D and SLEDAI after adjusting for age, seasonal variation and race (P = 0 . 018) (25) . However, after further adjustment for BMI, the relationship was no longer significant.…”

Section: Seasonal Variation and Disease Activity In Systemic Lupus Ermentioning

confidence: 99%

“…001) independent of age, SLEDAI and HCQ (24) 177 SLEDAI Higher 25(OH)D was associated with lower SLEDAI (P = 0 . 038) (25) 181 SLEDAI and SDI 25(OH)D was associated with SLEDAI (b = -0 . 715, P = 0 .…”

Section: Seasonal Variation and Disease Activity In Systemic Lupus Ermentioning

confidence: 99%

“…Over the past 15 years, and in particular in the last 5 years, research has reported that SLE patients have significantly lower vitamin D status than their healthy counterparts (12,(17)(18)(19)(20)(21) . Some have reported an association between vitamin D status and disease activity with lower vitamin D status contributing to greater disease activity (17)(18)(19)(20)(22)(23)(24)(25) . An association between vitamin D and fatigue has also been reported (16,26) ; however, not all studies have observed a relationship between vitamin D and indices of disease activity in SLE (27)(28)(29)(30) .…”

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confidence: 99%

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An evaluation of vitamin D status in individuals with systemic lupus erythematosus

et al. 2011

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Systemic lupus erythematosus (SLE) is a multi-system inflammatory disease where genetic susceptibility coupled with largely undefined environmental factors is reported to underlie the aetiology of the disease. One such factor is low vitamin D status. The primary source of vitamin D is endogenous synthesis following exposure of the skin to UVB light. Photosensitivity, sunlight avoidance and the use of sun protection factor in combination with medications prescribed to treat the symptoms of the disease, puts SLE patients at increased risk of vitamin D deficiency. Decreased conversion of 25-hydroxyvitamin D to the metabolically active form, 1,25-dihydroxyvitamin D 3 , is possible, due to renal impairment common in SLE putting additional stress on vitamin D metabolism. The majority of studies have identified low 25-hydroxyvitamin D in SLE patients, albeit using varying cut-offs ( < 25 to < 80 nmol/l). Of these studies, fifteen have investigated a link between status and disease activity with conflicting results. Variation with disease activity index measures used alongside methodological limitations within the study design may partially explain these findings. This review discusses the importance of optimal vitamin D status in SLE, critically evaluates research carried out to date that has investigated vitamin D in SLE, and highlights the need for a well-designed observational study that controls for diet, medication use, dietary supplements, UV exposure and seasonality, that uses sensitive methods for measuring vitamin D status and disease activity in SLE to conclusively establish the role of vitamin D in SLE.

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Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage

Ruiz‐Irastorza¹,

Gordo²,

Olivares³

et al. 2010

Arthritis Care & Research

135

124

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25‐hydroxyvitamin D and cardiovascular risk factors in women with systemic lupus erythematosus

Cited by 105 publications

References 48 publications

Vitamin D Deficiency and Pseudofractures in Child-Bearing Egyptian Women: Successful Medical Treatment Helps to Avoid Fractures and Surgical Interference

Vitamin D Deficiency and Pseudofractures in Child-Bearing Egyptian Women: Successful Medical Treatment Helps to Avoid Fractures and Surgical Interference

An evaluation of vitamin D status in individuals with systemic lupus erythematosus

Changes in vitamin D levels in patients with systemic lupus erythematosus: Effects on fatigue, disease activity, and damage

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