25-Hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis

Sempos, Christopher T.; Binkley, Neil

doi:10.1017/s1368980019005251

Cited by 70 publications

(50 citation statements)

References 82 publications

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“…(29,30) It is also possible in certain (31) Importantly, vitamin D research data are plagued by variation in the quality of serum total 25OHD assay methods-which has compromised, and continues to compromise-the ability to distinguish among the different guidelines currently in use. (32) Similarly, uncertainty about the quality of free 25OHD measurement hinders its evaluation compared with serum total 25OHD. For 25OHD and 24,25(OH)D 2 , reference methods are available that are used to improve the standardization of these analytes.…”

Section: Vitamin D Deficiency Is Prevalentmentioning

confidence: 99%

Controversies in Vitamin D: A Statement From the Third International Conference

et al. 2020

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The Third International Conference on Controversies in Vitamin D was held in Gubbio, Italy, September 10–13, 2019. The conference was held as a follow‐up to previous meetings held in 2017 and 2018 to address topics of controversy in vitamin D research. The specific topics were selected by the steering committee of the conference and based upon areas that remain controversial from the preceding conferences. Other topics were selected anew that reflect specific topics that have surfaced since the last international conference. Consensus was achieved after formal presentations and open discussions among experts. As will be detailed in this article, consensus was achieved with regard to the following: the importance and prevalence of nutritional rickets, amounts of vitamin D that are typically generated by sun exposure, worldwide prevalence of vitamin D deficiency, the importance of circulating concentrations of 25OHD as the best index of vitamin D stores, definitions and thresholds of vitamin D deficiency, and efficacy of vitamin D analogues in the treatment of psoriasis. Areas of uncertainly and controversy include the following: daily doses of vitamin D needed to maintain a normal level of 25OHD in the general population, recommendations for supplementation in patients with metabolic bone diseases, cutaneous production of vitamin D by UVB exposure, hepatic regulation of 25OHD metabolites, definition of vitamin D excess, vitamin D deficiency in acute illness, vitamin D requirements during reproduction, potential for a broad spectrum of cellular and organ activities under the influence of the vitamin D receptor, and potential links between vitamin D and major human diseases. With specific regard to the latter area, the proceedings of the conference led to recommendations for areas in need of further investigation through appropriately designed intervention trials. © 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.

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Section: Vitamin D Deficiency Is Prevalentmentioning

confidence: 99%

Controversies in Vitamin D: A Statement From the Third International Conference

et al. 2020

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“…Levels of 25(OH)D between 30 and 50 ng/mL are generally regarded to be optimal levels; however, a number of variables, including race and age, add complexity [6]. A more thorough discussion of vitamin D assay standardization and recommendation guidelines is provided by Sempos and Binkley [9]. In any case, the categories of vitamin D sufficiency or deficiency are based on the classic function of vitamin D, bone health.…”

Section: Vitamin D Basicsmentioning

confidence: 99%

“…For example, the recommendations and sufficiency numbers do not take into account an almost complete lack of data from Africa and South America [13••]. One recent editorial goes so far as to say that "vitamin D guidelines development is in a state of paralysis" due to a lack of agreement on the parameters for the terms insufficiency, sufficiency, and toxicity based on 25(OH)D concentrations [9]. Further, the commentary urges that a set of recommendations based on work of the Vitamin D Standardization Program (VDSP) paves the way for development of rational universal vitamin D status guidelines.…”

Section: Vitamin D Intake Recommendations Evaluation Of Sufficiencymentioning

confidence: 99%

Vitamin D Update

Matsui

2020

Curr Derm Rep

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Purpose The goal of this review is to provide an update in the field of vitamin D, in particular, the role of vitamin D in nonskeletal health, the complexity of providing patient guidance regarding obtaining sufficient vitamin D, and the possible involvement of vitamin D in morbidity and mortality due to SARS-CoV-2 (COVID-19). Recent Findings In addition to bone health, vitamin D may play a role in innate immunity, cardiovascular disease, and asthma. Although rickets is often regarded as an historical disease of the early twentieth century, it appears to be making a comeback worldwide, including "first-world" countries. Broad-spectrum sunscreens (with high UVA filters) that prevent erythema are unlikely to compromise vitamin D status in healthy populations. Summary New attention is now focused on the role of vitamin D in a variety of diseases, and more individualized patient recommendation schemes are being considered that take into account more realistic and achievable goals for achieving sufficient vitamin D through diet, supplements, and sun behavior.

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“…Although intraperitoneal insulin increased the 25(OH)D concentration in the hepatic vein, long-term intraperitoneal insulin treatment did not affect the 25(OH)D concentration when compared with subcutaneous insulin treatment in patients with T1DM [46]. Moreover, from the perspective of the Nutrition Society, the guidelines for vitamin D supplementation and assay standard of 25 (OH)D concentration are in a standstill period [47]. The nutritional guideline from Netherlands [48] suggests that a serum 25(OH)D concentration of >30 nmol/L is sufficient for individuals except for adults above the age of 70 years whose target serum 25(OH)D concentration is beyond 50 nmol/L.…”

Section: Discussionmentioning

confidence: 96%

A dose–response meta-analysis between serum concentration of 25-hydroxy vitamin D and risk of type 1 diabetes mellitus

et al. 2020

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It remains debatable whether vitamin D plays any role as a risk factor for type 1 diabetes mellitus (T1DM). We have summarized the effect of circulating 25-hydroxy vitamin D [25(OH)D] concentration on the risk of developing T1DM via a dose–response meta-analysis. We undertook a database search on PubMed, Embase, and Cochrane Library from inception to January 2020. A meta-analysis based on random-effects model was applied. Subgroup analysis and meta-regression were performed to inspect the source of heterogeneity. Dose–response data were examined using the generalized least squares trend estimation method. This study was registered with the PROSPERO (ID: CRD42020166174). In total, 16 studies including 10,605 participants (3913 case patients) were included. The pooled odds ratios (OR) and 95% confidence intervals (95% CI) for the highest versus the lowest 25(OH)D concentration was 0.39 (0.27, 0.57), with a high heterogeneity (I2 = 76.7%, P < 0.001). Meta-regression analysis identified latitude (P = 0.02), adjustment for gender (P = 0.001), and 25(OH)D stratification (P < 0.001) as sources of heterogeneity. Furthermore, the nonlinear dose–response analysis determined the OR (95% CI) of T1DM to be 0.91 (0.90, 0.93) per 10 nmol/L increase in the 25(OH)D concentration. A ‘U’-shaped association was found between serum 25(OH)D concentration and risk of T1DM. The present study highlights the significant inverse association between the circulating 25(OH)D concentration and the risk of T1DM.

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25-Hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis

Cited by 70 publications

References 82 publications

Controversies in Vitamin D: A Statement From the Third International Conference

Controversies in Vitamin D: A Statement From the Third International Conference

Vitamin D Update

A dose–response meta-analysis between serum concentration of 25-hydroxy vitamin D and risk of type 1 diabetes mellitus

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