25-hydroxyvitamin D insufficiency and inflammation increase cardiovascular risk in older people

Vieira, Nathalia Fidelis Lins; Nascimento, Carlos Queiroz do; Nascimento, Janaína da Silva; Vasconcelos, Sandra Mary Lima; Neto, João Araújo Barros; Santos, Ana Célia Oliveira dos

doi:10.1016/j.exger.2022.111864

Experimental Gerontology

2022

DOI: 10.1016/j.exger.2022.111864

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25-hydroxyvitamin D insufficiency and inflammation increase cardiovascular risk in older people

Nathalia Fidelis Lins Vieira

Carlos Queiroz do Nascimento²,

Janaína da Silva Nascimento³

et al.

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Cited by 2 publications

References 26 publications

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Exploring the Relationship between Lipid Profile, Inflammatory State and 25-OH Vitamin D Serum Levels in Hospitalized Patients

Bucurica,

Nancoff,

Dutu

et al. 2024

Biomedicines

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Anomalies in lipid metabolism involve multifactorial pathogenesis, among other factors, being associated with an inflammatory state and disturbances in vitamin D status. The literature has focused on the binary relationships between inflammation and dyslipidemia, vitamin D and dyslipidemia, or vitamin D and inflammation. Our study aimed to explore the link between all these three factors: 25-OH vitamin D serum levels, the presence of inflammation assessed through serum C-reactive protein (CRP), and serum lipid profile in 2747 hospitalized patients. Our results showed a positive correlation of HDL-C with 25 (OH) vitamin D and a negative correlation of HDL-C with CRP. This relationship had different patterns in the statistical network analysis. The network analysis patterns are preserved for males and females, except for the relationship between CRP and vitamin D, which is present in male cases and absent in females. The same triangular relationship between all three—CRP, vitamin D, and HDL-C was found with different strengths of partial correlation in obese and non-obese patients. This pattern was similar in patients with and without fatty liver. A shifted pattern was found in the network analysis of hypertensive patients. The CRP was negatively correlated with vitamin D and HDL-C, and vitamin D was positively correlated with HDL-C in non-hypertensive patients. Castelli’s Risk indexes I and II were positively associated with CRP, suggesting that increased cardiovascular risk is proportional to an inflammatory state. The triad formed by altered serum lipid levels, inflammation, and vitamin D represents a complex relationship marked by specific dynamics between lipidic fractions such as HDL-C and C-reactive protein and vitamin D.

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Exploring the Relationship between Lipid Profile, Inflammatory State and 25-OH Vitamin D Serum Levels in Hospitalized Patients

Bucurica,

Nancoff,

Dutu

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

Vitamin D Fortification and Its Effect on Athletes’ Physical Improvement: A Mini Review

Cong

Song

Chalamaiah

et al. 2023

Foods

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Poor vitamin D status is a widespread problem regardless of age and sex, emphasizing the necessity of new food sources to improve vitamin D levels. Currently, approximately 60% of dietary vitamin D consumption occurs via fortified foods. Vitamin D insufficiency (50–90%) is widespread according to age and region, despite different levels of sunlight exposure. The food industry must identify more effective strategies to increase normal dietary vitamin D intake and improve overall health. Strategies for vitamin D fortification include bioaddition, wherein a vitamin D-rich food source is added to staple foods during processes. These bioadditive strategies expand the range of vitamin D-containing foods and appeal to different preferences, cultures, and economic statuses. In several countries, vitamin D deficiency places athletes at a high risk of disease susceptibility. Due to low sun exposure, athletes in countries with higher and lower levels of sunlight have similar risks of vitamin D deficiency. In this review, we summarize recent technical advances to promote vitamin D utilization by humans during sports activities and in relation to the normal practices of athletes.

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25-hydroxyvitamin D insufficiency and inflammation increase cardiovascular risk in older people

Cited by 2 publications

References 26 publications

Exploring the Relationship between Lipid Profile, Inflammatory State and 25-OH Vitamin D Serum Levels in Hospitalized Patients

Exploring the Relationship between Lipid Profile, Inflammatory State and 25-OH Vitamin D Serum Levels in Hospitalized Patients

Vitamin D Fortification and Its Effect on Athletes’ Physical Improvement: A Mini Review

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