25-Hydroxyvitamin D is closely related with the function of the pancreatic islet β cells

Guo, Jingjing; Xiao, Zhengda; Xue, Xindong; Liu, Xin; Lü, Yan; Yin, Xiaolin; Ma, Kun

doi:10.12669/pjms.293.2982

Cited by 14 publications

(10 citation statements)

References 7 publications

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“…The role of vitamin D in the function of pancreatic cells can be mediated by the union of 1,25-dihydroxyvitamin D to its receptors in the beta cell. Alternatively, vitamin D can work through the activation of 25 hydroxyvitamin D (25OHD) by 1-alpha- hydroxylase expressed in pancreatic beta cells, directly improving insulin sensitivity by stimulating insulin receptor expression and the activation of PPAR-δ (peroxisome proliferator activated receptor delta), which has been associated to the regulation of fatty acid metabolism in skeletal muscle and adipose tissue [ 88 - 91 ].…”

Section: Vitamins and Diabetesmentioning

confidence: 99%

Vitamins and Type 2 Diabetes Mellitus

Valdés‐Ramos¹,

Laura²,

Elina³

et al. 2015

EMIDDT

156

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The present review evaluates the relationship between type 2 diabetes mellitus and individual or combined vitamins. Antioxidant vitamins A, C and E are found decreased in diabetic subjects, possibly due to an increased need to control the excessive oxidative stress produced by abnormalities in glucose metabolism. On the other hand, retinol binding protein exerts a modulating effect, as it has adipokine functions. With respect to the B group vitamins, thiamin, pyridoxine and biotin have been found decreased but the mechanisms are not clear, however supplementation has shown some improvement of the metabolic control in diabetic patients. The absorption of folic acid and vitamin B12 is importantly decreased by the prolongued use of metformin, which is the first choice drug in uncomplicated diabetes, thus these two nutrients have been found deficient in the disease and most probably need to be supplemented regularly. On the other hand, vitamin D is considered a risk factor for the development of diabetes as well as its complications, particularly cardiovascular ones. Although some studies have found an association of vitamin K intake with glucose metabolism further research is needed. Studies on the use of multivitamin supplements have shown unconclusive results. After reviewing the evidence, no real recommendation on the use of vitamin supplements in type 2 diabetes mellitus can be issued, however patients using metformin during prolongued periods may need folic acid and vitamin B12.

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Section: Vitamins and Diabetesmentioning

confidence: 99%

Vitamins and Type 2 Diabetes Mellitus

Valdés‐Ramos¹,

Laura²,

Elina³

et al. 2015

EMIDDT

156

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“…VitD, and its locally active metabolite 1,25-dihydroxyvitamin D 3, have been reported to interfere with insulin production [9] and type 2 diabetes [10], have anti-inflammatory function [11] as well as ability to suppress secretion of Receptor activator of nuclear factor κ-B ligand, Tumor necrosis factor α, Interleukin 6 and 17 and Interferon-γ in rheumatoid arthritis patients [12]. Following this wide range of effects on infection mediators, VitD has also been reported directly or indirectly associated with cardiovascular disease [13], rheumatoid arthritis [14, 15], osteoporosis [16, 17] as well gingival inflammation [18] and destructive periodontal disease [19–24].…”

Section: Introductionmentioning

confidence: 99%

Radiographic alveolar bone level and levels of serum 25-OH-Vitamin D3 in ethnic Norwegian and Tamil periodontitis patients and their periodontally healthy controls

et al. 2019

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Background Studies suggest association between low serum 25-OH-Vitamin D 3 (VitD) and chronic destructive periodontal diseases. The main sources of VitD is sun exposure and fat fish. Subjects with dark skin will therefore generate less VitD as response to sun exposure. The aim of the study was to assess the radiographic bone level and levels of serum VitD in ethnic Norwegian and Tamil periodontitis patients and their respective healthy controls. Methods Twenty-seven Tamil periodontitis patients living in Norway were compared to 21 Tamil controls as well as to 21 Norwegian periodontitis patients and 23 Norwegian controls. Marginal bone level was diagnosed on radiographs. VitD levels were diagnosed in blood samples by high-performance liquid chromatography-mass spectrometry. Results VitD levels were lower in Norwegian periodontitis patients than in controls, while no significant differences were observed between Tamil periodontitis patients and controls despite the significant difference between RBL between the periodontitis patients and controls in both groups. When calculating the odds ratio for having periodontal disease in both populations together, it appeared that one unit increased serum VitD (i.e. 1 nmol/L) decreased the odds of having radiographic bone loss by 4%. Conclusion According to logistic regression, and after correcting for confounding factors, VitD levels showed significant association with the presence of periodontitis, as expressed by radiographic bone loss, in all patients combined. Electronic supplementary material The online version of this article (10.1186/s12903-019-0769-6) contains supplementary material, which is available to authorized users.

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“…Diabetes, a disease that results from the interaction of genetic factors and environmental factors, is one of the most common endocrine diseases worldwide. ( 1 , 2 ) Increased insulin resistance and decreased beta cell function are known to play a role in the pathogenesis of type 2 diabetes. ( 3 )…”

Section: Introductionmentioning

confidence: 99%

Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults

Yoon

Jeon²,

Park

et al. 2016

J. Clin. Biochem. Nutr.

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The purpose of this study is to look at these relationships in non-diabetic Korean adults. This study was based on data from the KNHANES V-1, which is representative of the population of Korea. A total of 5,492 participants (≥20 years in age) without type 1 or type 2 diabetes, assessed for serum 25-hydroxyvitamin D [25(OH)D], fasting blood glucose and insulin, as well as anthropometric variables, were included in the analyses. The key study results were as follows: First, vitamin D status [vitamin D deficient, 25(OH)D <25 nM; vitamin D insufficient, 25(OH)D ≥25, <50 nM; vitamin D sufficient, 25(OH)D ≥50 nM] was inversely associated with homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in model 2 (adjusted for age and gender) and 3 (further adjusted for smoking, alcohol drinking, regular exercise, systolic and diastolic blood pressure, waist circumference, and body mass index). Second, in model 4, when further adjusted for total cholesterol, triglycerides, and HDL-C, vitamin D status was inversely associated with HOMA-B. However, association of vitamin D status and HOMA-IR was no longer significant. In conclusion, vitamin D was inversely associated with beta cell function in non-diabetic Korean adults but was not associated with insulin resistance.

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25-Hydroxyvitamin D is closely related with the function of the pancreatic islet β cells

Cited by 14 publications

References 7 publications

Vitamins and Type 2 Diabetes Mellitus

Vitamins and Type 2 Diabetes Mellitus

Radiographic alveolar bone level and levels of serum 25-OH-Vitamin D3 in ethnic Norwegian and Tamil periodontitis patients and their periodontally healthy controls

Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults

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