25-Hydroxyvitamin D serum level in Hashimoto&amp;rsquo;s thyroiditis, but not Graves&amp;rsquo; disease is relatively deficient

Ke, Wencai; Sun, Tiange; Zhang, Yanan; He, Leqi; Wu, Qiang; Liu, Jun; Zha, Bingbing

doi:10.1507/endocrj.ej16-0547

Cited by 60 publications

(58 citation statements)

References 26 publications

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“…In the majority of studies regarding Hashimoto's thyroiditis (HT), in HT patients calcidiol concentrations were lower and the prevalence of vitamin D deficiency was higher when compared with healthy controls (34,35,40,(51)(52)(53). It was confirmed in metaanalysis performed by Wang et al for the subgroup of patients with HT (43).…”

Section: Hashimoto's Thyroiditismentioning

confidence: 89%

“…In multivariate logistic regression analysis, every 5 nmol/l decrease in serum 25(OH)D 3 concentration was associated with a 1.55-fold (95% CI 1.18-2.02) increase in GD risk (38). Other authors, however did not observe differences in vitamin D status between subjects with GD and non-AITD patients (20) or healthy subjects (11,53). In two meta-analyses including 13 and 26 studies patients with GD had lower 25(OH)D 3 compared to controls (SMD = -1.04, 95% CI: -1.52 to -0.57 and SMD = -0.77, 95% CI -1.12 to -0.42, respectively), and were more likely to have vitamin D deficiency (OR = 3.50, 95% CI 1.86-6.56 and OR = 2.24, 95% CI 1.31-3.81, respectively) (43, 61).…”

Section: Graves' Diseasementioning

confidence: 91%

“…Kim demonstrated, that patients HT and with overt hypothyroidism had significantly more often vitamin D insufficiency (60.4 vs. 44.1 and 21.7%, respectively, p < 0.001) and lower 25(OH)D 3 levels (80.1 ± 47.7 vs. 99.34 ± 61.2 and 110.3 ± 69.9 nmol/l, respectively, p = 0.009) compared with those with euthyroidism and subclinical hypothyroidism (20). In the study of Ke et al vitamin D deficiency, defined as serum 25(OH)D 3 < 20 ng/ml, was also significantly more often in HT patients with overt hypothyroidism treated with L-thyroxin compared with euthyroid mild HT patients (70.3 vs. 55.4%, p < 0.05) (53). In the study of Mazokopakis et al including 218 HT patients there was a significant negative correlation only between serum 25(OH)D 3 and anti-TPO concen-trations and anti-TPO levels were significantly higher in 186 vitamin D deficient subjects compared to 32 those with no vitamin D deficiency (364 ± 181 IU/ml vs. 115.8 ± 37.1 IU/ml, p < 0.0001) (37).…”

Section: Hashimoto's Thyroiditismentioning

confidence: 93%

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Vitamin D and autoimmune thyroid diseases

Kochman¹

2017

PNM

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S u m m a r yVitamin D is one of the most important factors regulating calciuam and phosphorus homeostasis and bone metabolism. In the last years increasing evidences suggest an important role of vitamin D deficiency in many extra-skeletal disorders, such as metabolic syndromes, cardiovascular diseases, cancers, infections and autoimmune disorders, including rheumatoid arthritis, Crohn disease, multiple sclerosis and type 1 diabetes mellitus. Many studies has shown also an association of vitamin D deficiency with occurrence and development of autoimmune thyroid diseases including Hashimoto's thyroiditis, postpartum thyroiditis and Graves' disease. In recent years there are increasing data indicating that vitamin D supplementation may prevent these pathologies or alleviate their course. Some studies suggest also that vitamin D may influence thyroid function. This review presents current data on the relationship of vitamin D and thyroid autoimmunization and function. The effects of vitamin D supplementation on the development and progression of autoimmune thyroid disease have also been discussed. S t r e s z c z e n i e Witamina D jest jednym z głównych czynników regulujących homeostazę wapnia i fosforu oraz metabolizm kostny. W ostatnich latach coraz więcej dowodów wskazuje na ważną rolę niedoboru witaminy D w wielu schorzeniach spoza układu kostnego, takich jak zespoły metaboliczne, choroby układu sercowo-naczyniowego, nowotwory, infekcje oraz zaburzenia autoimmunizacyjne, w tym reumatoidalne zapalenie stawów, choroba Leśniowskiego-Crohna, stwardnienie rozsiane czy cukrzyca typu 1. Wiele badań wykazało także związek między niedoborem witaminy D a chorobami autoimmunizacyjnymi tarczycy, w tym zapaleniem tarczycy Hashimoto, poporodowym zapaleniem tarczycy i chorobą Gravesa-Basedowa. W ostatnich latach coraz więcej danych wskazuje na to, że uzupełnianie niedoboru witaminy D może zapobiegać tym patologiom lub łagodzić ich przebieg. Niektóre badania sugerują także, że witamina D może mieć wpływ na czynność hormonalną gruczołu tarczowego. W artykule przedstawiono najnowsze doniesienia dotyczące związku witaminy D z procesami autoimmunizacyjnymi w tarczycy i jej czynnością hormonalną. Omówiono także wpływ suplementacji witaminą D na rozwój i przebieg autoimmunizacyjnych chorób tarczycy.

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Section: Hashimoto's Thyroiditismentioning

confidence: 89%

Section: Graves' Diseasementioning

confidence: 91%

Section: Hashimoto's Thyroiditismentioning

confidence: 93%

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Vitamin D and autoimmune thyroid diseases

Kochman¹

2017

PNM

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“…Modungo et al found elevated anti-TPO and anti-TG antibodies in patients with po-REVIEW peutic doses reduced the level of anti-TG antibodies in patients with HT [33][34]. On the other hand, a decreased level of vitamin D can be observed in HT due to an elevated TSH level caused by hypothyroidism [21,22]. Persistently low levels of vitamin D increase the risk of many diseases, including osteoporosis.…”

Section: Benign Paroxysmal Positional Vertigomentioning

confidence: 99%

“…In the first stage of the disease, transient subclinical hyperthyroidism may occur due to the release of excess thyroid hormones from the damaged thyroid cells. The risk factors for HT include genetic and environmental factors such as impaired intake of iodine, iron, and selenium, chronic inflammation, and adverse effects of chemotherapeutic agents [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]

Miśkiewicz-Orczyk

Lisowska

Kajdaniuk

et al. 2020

Endokrynologia Polska

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Vertigo and balance disorders are common symptoms reported by approximately 15-20% of the adult population worldwide. For many years thyroid diseases have been suspected as the cause of vertigo by ENT physicians. Almost every patient hospitalised due to severe vertigo is investigated for thyroid disease as a suspected cause of acute vestibulopathy. The issue presented in this paper is related to a difficult and poorly understood relationship between autoimmune thyroid disease and peripheral vertigo. (Endokrynol Pol 2020; 71 (1): 76-81) Artykuł jest tłumaczeniem pracy: Katarzyna A. Miśkiewicz-Orczyk, Grażyna Lisowska, Dariusz Kajdaniuk, Mateusz Wojtulek. Can Hashimoto's thyroiditis cause vertigo? Endokrynol Pol 2020; 71 (1): 76-81. Należy cytować wersję pierwotną. Piśmiennictwo dostępne w wersji pierwotnej na stronach 79-81. Endokrynologia Polska Volume/Tom 71; Number/Numer 1/2020

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Serum 25-hydoxyvitamin D concentrations in relation to Hashimoto’s thyroiditis: a systematic review, meta-analysis and meta-regression of observational studies

Štefanić

Tokić

2019

Eur J Nutr

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25-Hydroxyvitamin D serum level in Hashimoto’s thyroiditis, but not Graves’ disease is relatively deficient

Cited by 60 publications

References 26 publications

Vitamin D and autoimmune thyroid diseases

Vitamin D and autoimmune thyroid diseases

Can Hashimoto's thyroiditis cause vertigo? [Czy choroba Hashimoto może być przyczyną zawrotów głowy?]

Serum 25-hydoxyvitamin D concentrations in relation to Hashimoto’s thyroiditis: a systematic review, meta-analysis and meta-regression of observational studies

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