25-Hydroxyvitamin D therapy in children with active juvenile rheumatoid arthritis: Short-term effects on serum osteocalcin levels and bone mineral density

Reed, Ann M.; Haugen, Maureen; Pachman, Lauren M.; Langman, Craig B.

doi:10.1016/s0022-3476(05)82424-2

Cited by 57 publications

(35 citation statements)

References 7 publications

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“…19 In a study, radial bone mineral density of children with JIA was measured repeatedly and inflammatory changes were followed for a 3 year period and it was shown that when the disease was inactive, the serum osteocalcin levels increased to normal levels. 25 IGF-1 levels of the study group were significantly lower than the control group. This was correlated with the decrease in BMD and SDS-2.…”

Section: Discussionmentioning

confidence: 58%

Growth and bone mineralization in patients with juvenile idiopathic arthritis

Okumus¹,

Ergüven

Devecí

et al. 2008

Indian J Pediatr

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Section: Discussionmentioning

confidence: 58%

Growth and bone mineralization in patients with juvenile idiopathic arthritis

Okumus¹,

Ergüven

Devecí

et al. 2008

Indian J Pediatr

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“…Another limitation of our study was the lack of data on calcium and vitamin D intake, due to the retrospective design of the study. Although calcium supplementation has been shown to be of benefit in maintaining normal BMD increase in healthy prepubertal children (7), studies of children with rheumatic diseases have yielded conflicting results (14,16,(48)(49)(50). Similarly, we did not evaluate the effect of activity on BMD, due to the retrospective study design.…”

Section: Discussionmentioning

confidence: 97%

Prevalence and etiology of low bone mineral density in juvenile systemic lupus erythematosus

Compeyrot-Lacassagne¹,

Tyrrell²,

Atenafu³

et al. 2007

Arthritis & Rheumatism

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Objective. Studies of adults with systemic lupus erythematosus (SLE) have frequently demonstrated the presence of decreased bone mineral density (BMD).However, there have been few investigations in pediatric patients to date. This study was undertaken to determine the prevalence of low BMD in patients with juvenile SLE and to identify associated risk factors.Methods. We studied 64 consecutive patients with juvenile SLE in whom routine dual x-ray absorptiometry (DXA) scanning was performed. Lumbar spine osteopenia was defined as a BMD Z score of <؊1 and >؊2.5, and osteoporosis as a BMD Z score of <؊2.5. Decreased hip BMD was defined as a value of <80%. Data on disease activity, quality of life, disease-related damage, sex, ethnicity, body mass index, age at diagnosis, age at DXA, medication use and duration, clinical features, and puberty status were collected at the time of DXA.Results. Lumbar spine osteopenia was seen in 24 patients (37.5%) and osteoporosis in 13 (20.3%). Decreased hip BMD was present in 12 patients (18.8%). By univariate analysis, osteopenia was significantly correlated with age, disease duration, duration of corticosteroid use, cumulative corticosteroid dose, azathioprine use, cyclophosphamide use, lupus nephritis, and damage. Two additional variables, mycophenolate mofetil use and class III-IV nephritis, were associated with osteoporosis. Abnormal hip BMD was associated with disease duration, duration of corticosteroid use, and cumulative corticosteroid dose. By multivariate analysis, only disease duration remained in the model for osteoporosis and abnormal hip BMD, while cumulative corticosteroid dose was the variable associated with osteopenia.Conclusion. These results indicate that osteopenia and osteoporosis are common in juvenile SLE and are associated more closely with increased disease duration than with cumulative corticosteroid dose.

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“…Surprisingly, they range from clear recommendations to the disapproval of routine supplementations. In small and uncontrolled pediatric studies, no consistent increase of BMD (measured by DXA) with supplementation of vitamin D and calcium has been shown [34]. In children with vitamin D deficiency, calcitriol therapy lead to an increase in BMD [6].…”

Section: Vitamin D and Calciummentioning

confidence: 99%

Osteoporosis in juvenile idiopathic arthritis- a practical approach to diagnosis and therapy

et al. 2007

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In all subgroups of juvenile idiopathic arthritis, a decrease in bone mass has been described in a high percentage of children. Recently, new pathogenetic concepts have identified muscle mass as the strongest predictor of bone mass and bone is now recognized as part of the musculoskeletal system. In addition, the sophisticated use of bone densitometry in pediatrics, including new measurement techniques, has provided the tools for a reliable assessment. A standardized diagnostic approach to the musculoskeletal system, including prophylaxis and therapy, is, therefore, mandatory in all children with JIA who do not achieve rapid remission. In this review, diagnostic and therapeutic options are being described and possibilities to incorporate them into clinical practice are suggested.

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25-Hydroxyvitamin D therapy in children with active juvenile rheumatoid arthritis: Short-term effects on serum osteocalcin levels and bone mineral density

Cited by 57 publications

References 7 publications

Growth and bone mineralization in patients with juvenile idiopathic arthritis

Growth and bone mineralization in patients with juvenile idiopathic arthritis

Prevalence and etiology of low bone mineral density in juvenile systemic lupus erythematosus

Osteoporosis in juvenile idiopathic arthritis- a practical approach to diagnosis and therapy

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