25. Novel adipokine tazarotene induced gene 2 correlations with increased cardiovascular risk determined by body composition, insulin resistance, dyslipidemia and diabesity in Saudi women

Habib, Shahid; Fatani, Dalal; Eshki, A.; AlTassan, B; Helmi, Hadeel; Alsaif, Seham

doi:10.1016/j.jsha.2016.04.026

Cited by 2 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…levels ultimately lead to DM progression. [26] Indeed, the risk of EC can decrease with improvement of IR and other metabolic abnormalities. [27] At present, the mechanism of IR in EC development remains unclear, and some biological pathways may be involved.…”

Section: Ir and Hyperinsulinemiamentioning

confidence: 99%

See 1 more Smart Citation

Diabetes mellitus and endometrial carcinoma: Risk factors and etiological links

et al. 2022

View full text Add to dashboard Cite

The presence of diabetes mellitus (DM) has a critical influence on the occurrence and development of endometrial cancer (EC) and is associated with a poor prognosis. Patients with DM are twice as likely to progress to EC, probably because a high-glucose environment contributes to the growth and invasiveness of EC cells. In this review, we focus on the etiological links between DM and EC and provide an overview of potential biological mechanisms that may account for this relationship, including hyperglycemia, insulin resistance, hyperinsulinemia, glycolysis, chronic inflammation, obesity, and activation of signaling pathways involved in EC. Furthermore, we discuss the pharmacological management of EC associated with DM. Early treatment with metformin is expected to be an effective adjuvant alternative for EC in the future. This knowledge is important for further opening up preventive and therapeutic strategies for EC by targeting glucose metabolism.

show abstract

Section: Ir and Hyperinsulinemiamentioning

confidence: 99%

“…Accompanied by the failure of pancreatic β-cells, increased blood glucose levels ultimately lead to DM progression. [26] Indeed, the risk of EC can decrease with improvement of IR and other metabolic abnormalities. [27]…”

Section: The Biological Mechanisms Linking Dm and Ecmentioning

confidence: 99%

Diabetes mellitus and endometrial carcinoma: Risk factors and etiological links

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In Saudi women with matched BMIs, chemerin levels were higher in women with T2D [30]. In a second study involving both sexes, the only groups with T2D that exhibited higher levels of chemerin than the subjects with normal BMIs were those with either obesity or severe obesity [45].…”

Section: Discussionmentioning

confidence: 87%

“…There is a correlation between chemerin levels, both total and cleaved, and body mass index (BMI) in individuals with obesity and T2D [19,28,29]. Furthermore, chemerin has been proposed as a prognostic marker for T2D and may serve as a mediator of insulin resistance [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

“…The correlation between BMI and chemerin levels is well researched [4,19,21,22,29,30,[33][34][35]; however, the relationship between T2D and chemerin levels has not been well documented in either individuals with a normal weight and T2D (NWD) or individuals with obesity and T2D (OWD) [32,36]. There is an increased activation and subsequent proteolysis of chem163S in both humans and mice with obesity [22,34,35].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemerin Levels in Individuals with Type 2 Diabetes and a Normal Weight versus Individuals with Type 2 Diabetes and Obesity: An Observational, Cross-Sectional Study

Mukherji,

Idowu,

Zhao

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Chemerin acts as both a chemotactic agent and an adipokine that undergoes proteolytic cleavage, converting inactive precursors into their active forms before being subsequently inactivated. Elevated chemerin levels are linked to obesity and type 2 diabetes mellitus (T2D). This study aimed to elucidate the effects of T2D and obesity on chemerin levels by comparing plasma samples from individuals with a normal weight and T2D (BMI < 25; NWD group n = 22) with those from individuals who are overweight or obese and have T2D (BMI ≥ 25; OWD group n = 39). The total chemerin levels were similar in the NWD and OWD groups, suggesting that T2D may equalize the chemerin levels irrespective of obesity status. The cleavage of chemerin has been previously linked to myocardial infarction and stroke in NWD, with potential implications for inflammation and mortality. OWD plasma exhibited lower levels of cleaved chemerin than the NWD group, suggesting less inflammation in the OWD group. Here, we showed that the interaction between obesity and T2D leads to an equalization in the total chemerin levels. The cleaved chemerin levels and the associated inflammatory state, however, differ significantly, underscoring the complex relationship between chemerin, T2D, and obesity.

show abstract

25. Novel adipokine tazarotene induced gene 2 correlations with increased cardiovascular risk determined by body composition, insulin resistance, dyslipidemia and diabesity in Saudi women

Cited by 2 publications

References 0 publications

Diabetes mellitus and endometrial carcinoma: Risk factors and etiological links

Diabetes mellitus and endometrial carcinoma: Risk factors and etiological links

Chemerin Levels in Individuals with Type 2 Diabetes and a Normal Weight versus Individuals with Type 2 Diabetes and Obesity: An Observational, Cross-Sectional Study

Contact Info

Product

Resources

About