250 Increased CXCL10 (IP-10) in Bronchoalveolar Lavage (BAL) Is Associated with Acute Rejection (ACR) in Lung Transplant Recipients (LTR)

Resende, Mariângela Ribeiro; Rajwans, Nimerta; Pilewski, Joseph M.; McCurry, K.R.; Keshavjee, S.; Liles, W. Conrad; Husain, Shahid

doi:10.1016/j.healun.2011.01.257

Cited by 1 publication

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“…IL-6 and IL-4 increases were found more often in patients with ACR than any other cytokines changes. Similarly, IL-6 protein was higher in lung transplant recipients with histopathogical proven ACR compared with infection and levels of IL-6 were significantly increased during moderate or severe ACR [ 39 ]. In another study, IL-6 mRNA in BAL was highest in patients with corticosteroid-refractory histologic ACR [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

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Plasma and bronchoalveolar lavage samples in acute lung allograft rejection: the potential role of cytokines as diagnostic markers

et al. 2017

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The role of differential cytology patterns in peripheral blood and bronchoalveolar lavage samples is increasingly investigated as a potential adjunct to diagnose acute and chronic allograft dysfunction after lung transplantation. While these profiles might facilitate the diagnosis of acute cellular rejection, low sensitivity and specificity of these patterns limit direct translation in a clinical setting. In this context, the identification of other biomarkers is needed. This review article gives an overview of cytokine profiles of plasma and bronchoalveolar lavage samples during acute cellular rejection. The value of these cytokines in supporting the diagnosis of acute cellular rejection is discussed. Current findings on the topic are highlighted and experimental settings for future research projects are identified.

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Section: Methodsmentioning

confidence: 99%

“…Increased CXCL10 has been associated with ACR in clinical studies [ 39 , 41 ]. CXCL-10 was higher in patients with ACR than in patients with infection [ 41 ].…”

Section: Methodsmentioning

confidence: 99%