256P Risk of CNS metastasis after neoadjuvant chemotherapy: Pathological complete response may not be enough

Abstract

presented an event of interest for DDFS analyses. Five-year DDFS was 91,6%. Predictors for DDFS in univariate analysis were cT stage (c2¼45.408, p<0.001), AJCC Anatomic Stage Groups (c2¼ 110,784, p<0.001), and AJCC Clinical Prognostic Stage Groups (c2¼ 22,868, p¼0.001). In the multivariate analyse only AJCC anatomic stage groups retained significative results for DDFS (p<0,001).Conclusions: In our study, after pCR in breast cancer patients treated with NACT, only AJCC anatomic stage groups was significant for DDFS in the multivariate analyse. In this special population, these results emphasize the importance of meticulous staging at diagnosis and suggest the possibility of personalised follow-up and modulated adjuvant treatment after surgery based on AJCC anatomic stage groups.Legal entity responsible for the study: The authors.