263 – Complement system and post-traumatic stress disorder

Hovhannisyan, Lilit; Mkrtchyan, G.; Boyajyan, Anna; Sukiasian, S.H.

doi:10.1016/j.schres.2007.12.330

Cited by 1 publication

(2 citation statements)

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“…at the level of the development of infl ammatory reactions in CNS and at the systemic level, can contribute to PTSD pathogenesis [5,7,10,13,14]. Previous studies revealed increased levels of proinfl ammatory cytokines in patients with PTSD [7,10,13], which agrees with our fi ndings.…”

Section: Resultssupporting

confidence: 92%

“…Previous studies revealed increased levels of proinfl ammatory cytokines in patients with PTSD [7,10,13], which agrees with our fi ndings. We previously revealed high levels of circulating immune complexes in PTSD patients [5], which are markers of autoimmune and infl ammatory reactions and known activators of classic complement cascade [2]. Our study showed, that PTSD patients also have disturbances in the complement system, an important component of the infl ammatory response.…”

Section: Resultssupporting

confidence: 56%

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Classic and Alternative Complement Cascades in Post-Traumatic Stress Disorder

et al. 2009

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Hemolytic activity of classic and alternative complement cascades and blood concentrations of TNF-α, IL-1β, and IL-6 were measured in patients with post-traumatic stress disorder. The results attest to hyperactivity of the classic complement cascade associated with elevated content of proinflammatory cytokines and hypoactivation of the alternative complement cascade in patients with post-traumatic stress disorder in comparison with healthy individuals.

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