27. Oral Immunoglobulins for Treatment of Acute Rotaviral Gastroenteritis

A Double-Blind, Placebo-Controlled Trial of Oral Human Immunoglobulin for Gastrointestinal Dysfunction in Children with Autistic Disorder

“…Additionally, there were no subjects with treatment-emergent serious AEs and only eight subjects discontinued the study due to AEs. These findings are in agreement with previous reports examining oral immunoglobulin in neonates (Barnes et al 1982) and children or adults with serious intestinal infections (Borowitz and Saulsbury 1991;Guarino et al 1994;Losonsky et al 1985;Tacket et al 1988;1992;Tjellstrom et al 1993Tjellstrom et al , 1997.…”

“…Despite this controversy, there are claims of a specific GI immunopathology associated with autism that suggest treatments such as oral immunoglobulin, may prove to be effective in treating the GI dysfunction in children with autism (Borowitz and Saulsbury 1991;Guarino et al 1994;Losonsky et al 1985;Tacket et al 1988;1992;Tjellstrom et al 1993Tjellstrom et al , 1997. There is some evidence to support the use of oral immunoglobulin in other GI disorders, but in many of these disorders the etiology and pathophysiology are better characterized, such as rotavirus diarrhea, chronic diarrhea in children with short-gut syndrome, and pseudomembranous colitis due to Clostridium difficile.…”

“…The use of immunoglobulin has not been studied in well controlled trials in patients with IBS. Oral immunoglobulin appears to be well-tolerated with no serious side effects reported in low birth weight neonates (Barnes et al 1982), children and adults with serious intestinal infections (Borowitz and Saulsbury 1991;Guarino et al 1994;Losonsky et al 1985;Tacket et al 1988;1992;Tjellstrom et al 1993Tjellstrom et al , 1997, and in healthy adult volunteers (Bogstedt et al 1995). Schneider et al (2006) previously conducted an 8 week prospective open-label pilot study using oral immunoglobulin (Oralgam) in 12 children with autism and persistent GI dysfunction.…”

The role of bovine colostrum on recovery time and length of hospital stay of acute diarrhea in infants and children: a double-blind randomized controlled trial

“…Similar results were reported by Ylitalo et al 8 12 in Bangladesh in which oral hyperimune bovine colostrum was effective to accelerate the recovery time and the length of hospital stay for acute diarrhea caused by rotavirus in infants and children compared with control of 56 hours compared to 72 hours. Guarino et al, 13 in Italy found the length of hospital stay was 76 hours in the group of acute diarrhea caused by rotavirus given antiviral human serum immunoglobulin compared to 131 hours in control group. In the Mieten et al's study, 14 bovine colostrum was given to 60 children with acute diarrhea by enteropathogenic E. coli (EPEC).…”

“…This could be due to the effects of bovine colostrum in shortening the excretion duration of virus, bacteria, parasite, and fungus in the patients' feces so that the transmission chain could be broken down faster and the possibility of transmission to the surrounded population would be smaller. 8,13 This was proved in the Sarker et al's study 9 which showed rotavirus excretion in the feces stopped faster in infants and children with acute diarrhea caused by rotavirus who were given bovine colostrums for 4 days compared to placebo, ie. 1.5 vs. 2.9 days.…”