27 Risk of hepatocellular carcinoma associated with genotypes and mutants of hepatitis B virus: A community-based prospective cohort study

Yang, Hwai I.; Chen, P.J.; Yeh, Shiou Hwei; Jen, C.-L.; You, San Lin; Chen, D.S.; Chen, C.J.

doi:10.1016/s0168-8278(06)80028-0

Cited by 3 publications

(3 citation statements)

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“…Our recent 14-year prospective study on 4,841 Taiwanese men who were HBV carriers also demonstrated that HBV genotype C was associated with an increased risk of HCC compared with other HBV genotypes (adjusted OR = 5.11, 95% CI = 3.20-8.18) [51]. A community-based prospective cohort study further showed that HBV genotype C was associated with the risk of HCC development [52]. These findings indicated that genotype C was correlated with a higher risk of developing HCC.…”

Section: Genotype and Subgenotypementioning

confidence: 86%

Role of viral factors in the natural course and therapy of chronic hepatitis B

Kao

2007

Hepatol Int

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Hepatitis B virus (HBV) infection is a global health problem that causes a wide spectrum of liver disease, including acute or fulminant hepatitis, inactive carrier state, chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). The pathogenesis of hepatocyte damage associated with HBV is mainly through immune-mediated mechanisms. On the basis of the virus and host interactions, the natural history of HBV carriers who are infected in early life can be divided into four dynamic phases. The frequency, extent, and severity of hepatitis flares or acute exacerbation in the second immune clearance and/or fourth reactivation phase predict liver disease progression in HBV carriers. In the past decade, hepatitis B viral factors including serum HBV DNA level, genotype, and naturally occurring mutants predictive of clinical outcomes have been identified. The higher the serum HBV DNA level after the immune clearance phase, the higher the incidence of adverse outcomes over time. In addition, high viral load, genotype C, basal core promoter mutation, and pre-S deletion correlate with increased risk of cirrhosis and HCC development. As to the treatment of chronic hepatitis B, patients with high HBV DNA level and genotype C or D infection are shown to have a worse response to interferon therapy. In conclusion, serum HBV DNA level, genotype, and naturally occurring mutants are identified to influence liver disease progression and therapy of chronic hepatitis B. More investigations are needed to clarify the molecular mechanisms of the viral factors involved in the pathogenesis of each stage of liver disease and the response to antiviral treatments.

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Section: Genotype and Subgenotypementioning

confidence: 86%

Role of viral factors in the natural course and therapy of chronic hepatitis B

Kao

2007

Hepatol Int

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“…The interactions among host, environmental, and viral factors have been reported to determine the natural course and treatment outcomes of individuals with chronic HBV infection 1 . In the past decade, several critical hepatitis B viral factors predictive of clinical outcomes have been identified 2–13 . Of particular note is the REVEAL–HBV study from Taiwan, which indicated that a higher baseline serum HBV‐DNA level conferred a higher risk of cirrhosis as well as HCC, even in hepatitis B e‐antigen (HBeAg)‐negative HBV‐infected people aged over 30 years after 13 years of follow up, especially in those with a persistently high viral load (>20 000 IU/mL) 12,13 …”

Section: Reported Associations Between Core Promoter Mutations and Dementioning

confidence: 99%

“…In addition to viral load, HBV genotype C (HBV/C), basal core promoter (BCP) A1762T/G1764A mutation, and the pre‐S deletion mutant also attracted much attention since they each have been shown to affect the progression of HBV‐related chronic liver disease 2–11 . Specifically, among the viral proteins produced by HBV, the X protein is a multifunctional regulator that modulates host transcription, cell responses to genotoxic stress, protein degradation, and signal transduction pathways 14 .…”

Section: Reported Associations Between Core Promoter Mutations and Dementioning

confidence: 99%