270 A Case Report on a Primary Hepatic Yolk Sac Tumor in a Middle-Aged Woman—A Challenging Diagnosis

Prilutskiy, Andrey; Tan, Josenia; Zhao, Qing

doi:10.1093/ajcp/aqx123.269

Cited by 3 publications

(9 citation statements)

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“…It may be beneficial to preoperatively differentiate HCC, hepatoblastoma, and primary hepatic YST, as the latter 2 respond well to systemic chemotherapy. [6,[14][15][16]22] Surgical resection is the established curative treatment for primary hepatic YST. The successful removal of tumors combined with preoperative or postoperative platinum-based chemotherapy [6,10,12,14,15] has been implemented in several patients with primary hepatic YST.…”

Section: Discussionmentioning

confidence: 99%

“…[6,[14][15][16]22] Surgical resection is the established curative treatment for primary hepatic YST. The successful removal of tumors combined with preoperative or postoperative platinum-based chemotherapy [6,10,12,14,15] has been implemented in several patients with primary hepatic YST. Welan et al described a patient with a primary hepatic YST who underwent successful liver tumor resection with preoperative adjuvant chemotherapy and achieved longterm survival (>5 years).…”

Section: Discussionmentioning

confidence: 99%

“…Most patients die within 1 year due to widespread disease [3,4,10] or a lack of follow-up outcomes. [5,9,[14][15][16][17] Limited data suggest that liver transplantation is an alternative treatment for primary hepatic YST. [11,23] In this study, we report a case of multiple unresectable hepatic YSTs with extrahepatic metastasis that underwent successful liver transplantation with concurrent surgical removal of the metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…only 15 adult cases reported to date in the English literature (Table 1). [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Owing to the lack of specific laboratory biomarkers and imaging manifestations, it is difficult to differentiate primary hepatic YST from hepatocellular carcinoma (HCC) and hepatoblastoma. Most primary hepatic YSTs are diagnosed by incidental preoperative biopsy or postoperative histopathological examination, and are characterized by the formation of the Shiller-Duval body, that is, central vessels surrounded by epithelial tumor cells and fibrous tissue.…”

Section: G-hl M-kq and Yw Contributed Equally To This Workmentioning

confidence: 99%

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Liver transplantation for advanced-stage primary hepatic yolk sac tumor: A case report and literature review

Liu,

Qiu,

Wang

et al. 2023

Medicine

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Rationale: Primary hepatic yolk sac tumors (YSTs) are rare in adults. Liver resection is an acknowledged treatment modality for primary hepatic YST. Liver transplantation may offer a possible cure for unresectable cases. Patient concerns: We present a case of a 31-year-old woman with an abdominal mass who had abnormally elevated alpha-fetoprotein (AFP) levels (31,132 ng/mL; normal: 0–7 ng/mL). Contrast-enhanced computed tomography (CT) revealed large tumors located in both lobes of the liver, with arterial enhancement and venous washout. Fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT indicated increased 18F-FDG uptake (maximum standardized uptake value, 24.4) in the liver tumors and left middle intra-abdominal nodule. Diagnoses: The diagnosis was primary hepatic YST with metastasis to the greater omentum. Interventions: The patient underwent orthotopic liver transplantation and intra-abdominal nodule resection after transarterial chemoembolization (TACE) as a bridge. Intraoperatively, an intra-abdominal nodule was confirmed in the greater omentum. Histopathological examination of the liver tumors revealed Schiller-Duval bodies. The tropomyosin receptor kinase (TRK) inhibitor larotrectinib was administered, followed by four cycles of chemotherapy with bleomycin, etoposide, and cisplatin based on the next-generation sequencing results. Outcomes: The AFP level decreased to within the normal range. No evidence of tumor collapse was observed during the 34-month follow-up period. Lessons: This case suggests that multimodal therapy dominated by liver transplantation, including preoperative TACE, postoperative adjuvant chemotherapy, and TRK inhibitors, is an effective treatment modality for unresectable primary hepatic YST.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: G-hl M-kq and Yw Contributed Equally To This Workmentioning

confidence: 99%

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Liver transplantation for advanced-stage primary hepatic yolk sac tumor: A case report and literature review

Liu,

Qiu,

Wang

et al. 2023

Medicine

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show abstract

“…Primary yolk sac tumor of the liver is extremely rare, and less than 15 adult cases have been reported to date. 1–5 Therefore, the collective description of clinicopathological features and outcomes of this tumor is sparse. We present a case of an unresectable primary yolk sac tumor of the liver in a young man, along with the review of literature, and peculiar features of this tumor.…”

Section: Introductionmentioning

confidence: 99%