27893 An advanced oil composition containing stabilized retinol with enhanced bioactivity using neocitrate

Meza, Daphne; Chang, Michael; Patel, Ruchi; Walsh, S.; Brillouet, Anne-Sophie; Parsa, Ramine

doi:10.1016/j.jaad.2021.06.679

Cited by 1 publication

(2 citation statements)

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“…Most commercially available retinol products contain 0.04%–1.0% although many products are not labeled accordingly 3 . Although it might seem logical that higher concentrations of retinol should be more effective, a comparative study demonstrated that stabilized 0.1% retinol upregulated CRABP II more than a 0.2% prestige brand 48 . This data underscores the importance of evaluating retinols on a product‐by‐product basis.…”

Section: Retinolmentioning

confidence: 98%

“…In the mid‐1990s formulators successfully stabilized retinol in cosmetic formulation 3 . Delivery systems such as microsponges and liposomes have been used to enhance stability and deliver retinol more gradually to the skin 31,32 . In addition, packaging such as airless pumps and tubes were used to extend the shelf‐life of cosmetic retinoids to 2 years 3 .…”

Section: Cosmetic Retinoidsmentioning

confidence: 99%

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Vitamin A: It's role in cosmeceuticals for antiaging

Farris

2023

Dermatological Reviews

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Topical retinoids are among the most well‐studied and widely used cosmeceutical ingredients. Topical retinoids have skin rejuvenating benefits and can soften fine lines and wrinkles, lighten mottled hyperpigmentation, improve skin roughness, sallowness, and overall appearance of photoaged skin. Retinoic acid or tretinoin remains favored among dermatologists because there are a plethora of well‐designed clinical trials confirming its efficacy as a topical therapy for treating aging skin. In contrast, cosmeceutical retinoids are regulated as cosmetics and in general are not subjected to the same degree of scientific rigor as prescription retinoids. Despite this difference, there are studies confirming the antiaging benefits of cosmeceutical retinoids and studies comparing their efficacy and tolerability to tretinoin. This review will focus on over‐the‐counter retinoids including retinol, retinaldehyde, retinyl esters, adapalene, and novel retinoid molecules. Studies on pharmacokinetics, mechanisms of action, clinical benefits, and tolerability will be reviewed.

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Section: Retinolmentioning

confidence: 98%

Section: Cosmetic Retinoidsmentioning

confidence: 99%