28.6 A ±50mV linear-input-range VCO-based neural-recording front-end with digital nonlinearity correction

Jiang, Wenlong; Hokhikyan, Vahagn; Chandrakumar, Hariprasad; Karkare, Vaibhav; Marković, Dejan

doi:10.1109/isscc.2016.7418118

Cited by 20 publications

(15 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although Neuro-stack is much smaller than other external systems, an even smaller version could be tested in future in-vivo studies since its IC chips are all implantable by design [29][30][31][32][33]37] and require a combined area of just 113 mm 2 (ICs from all layers, four analog and one digital). An implantable version of the Neuro-stack [30] but with its added single-neuron and closed-loop stimulation capabilities thus presents an exciting avenue towards a completely wireless intracranial single-unit and LFP recording system that would not be susceptible to motion artifacts.…”

Section: Discussionmentioning

confidence: 99%

“…The analog layer (Fig. 1b, bottom) contains mixed-signal sensing IC (Sense IC and Spike IC) and stimulation IC (Stim IC) chips, which were previously developed as part of the DARPA SUBNETS program [29][30][31][32]. A single Sense IC (one per analog layer) accepts neural activity from up to 64 electrode contacts fed into voltage-controlled oscillators (VCO), which serve as analog-digital converters (ADC).…”

mentioning

confidence: 99%

See 1 more Smart Citation

A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely-moving humans

Topalovic

Barclay

Ling

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Advancements in technologies that can record and stimulate deep-brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely-moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and lack full-duplex bi-directional capability. Here, we report a wearable bi-directional closed-loop neuromodulation system (Neuro-stack) that allows for the recording of single-neuron and local field potential activity during ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to develop improved responsive neuromodulation therapies, investigation of brain function during naturalistic behaviors in humans, and consequently, the bridging of decades of neuroscientific findings across species.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely-moving humans

Topalovic

Barclay

Ling

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…TD systems encode information with respect to the timing intervals of asynchronous digital signals to perform mixed signal processing while extensively using standard logic and oscillators that do not suffer from analogue complications. Many recent publications will indicate the potential for exceptional dynamic range like in the recording system of [3] or highly compact instrumentation like the potentiostat in [4]. We argue that a key advantage for these systems is that supply voltage is utilized more effectively from a fundamental aspect without being impeded by linearity.…”

Section: Introductionmentioning

confidence: 94%

A 0.5V time-domain instrumentation circuit with clocked and unclocked ΔΣ operation

Leene

Constandinou

2017

2017 IEEE International Symposium on Circuits and Systems (ISCAS)

View full text Add to dashboard Cite

Abstract-This paper presents a time-domain instrumentation circuit with exceptional noise efficiency directed at using nano metre CMOS for next generation neural interfaces. Current efforts to realize closed loop neuromodulation and high fidelity BMI prosthetics rely extensively on digital processing which is not well integrated with conventional analogue instrumentation. The proposed time-domain topology employs a differential ring oscillator that is put into feedback using a chopper stabilized low noise transconductor and capacitive feedback. This realization promises better digital integration by extensively using time encoded digital signals and seamlessly allows both clocked & unclocked ∆Σ behavior which is useful on-chip characterization and interfacing with synchronous systems. A 0.5 V instrumentation system is implemented using a 65 nm TSMC technology to realize a highly compact footprint that is 0.006 mm 2 in size. Simulation results demonstrate an excess of 55 dB dynamic range with 3.5 µVrms input referred noise for the given 810 nW total system power budget corresponding to an NEF of 1.64.

show abstract

“…This demonstrates that a passive implementation is impossible, and for this reason a better approach would be to employ pseudo-resistors. There have been several ways proposed to synthesize very high resistances, for instance, Jiang [2] used a switched resistor with a clock, but this requires an extra clock generator which is power hungry. Several people attempted to solve the problem with the subthreshold region based MOS resister [3], [6], and they achieved very a high resistance without consuming much power but poor linearity, therefore this is the approach considered here to synthesize a high value resistor whilst proposing a novel biasing technique to improve the linearity.…”

Section: Vin Voutmentioning

confidence: 99%

A High Value, Linear and Tunable CMOS Pseudo-Resistor for Biomedical Applications

Nagulapalli

Hayatleh

Barker

et al. 2019

J CIRCUIT SYST COMP

View full text Add to dashboard Cite

A subthreshold MOS-based pseudo-resistor featuring a very high value and ultra-low distortion is proposed. A bandpass neural amplifier with a very low high-pass cutoff frequency is designed, to demonstrate the linearity of the proposed resistor. A BJT less CTAT current generator has been introduced to minimize the temperature drift of the resistor and make tuning easier. The standalone resistor has achieved 0.5% better linearity and a 12% improved temperature coefficient over the existing architectures. A neural amplifier has been designed with the proposed resistor as a feedback element. It demonstrated 31[Formula: see text]dB mid-band gain and a low-pass cutoff frequency of 0.85[Formula: see text]Hz. The circuit operates from a 1[Formula: see text]V supply and draws 950[Formula: see text]nA current at room temperature.

show abstract

28.6 A ±50mV linear-input-range VCO-based neural-recording front-end with digital nonlinearity correction

Cited by 20 publications

References 4 publications

A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely-moving humans

A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely-moving humans

A 0.5V time-domain instrumentation circuit with clocked and unclocked ΔΣ operation

A High Value, Linear and Tunable CMOS Pseudo-Resistor for Biomedical Applications

Contact Info

Product

Resources

About