28-days dietary supplementation with golden flaxseed improves biochemical and oxidative parameters in patients with metabolic syndrome

Pilar, Bruna Cocco; Güllich, Angélica Aparecida da Costa; Ströher, Deise Jaqueline; Zuravski, Luísa; Mezzomo, Juliana; Coelho, Ritiéle Pinto; Faoro, Débora; Piccoli, Jacqueline da Costa Escobar; Manfredini, Vanusa

doi:10.1016/j.jff.2014.06.020

Cited by 20 publications

(17 citation statements)

References 67 publications

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“…Furthermore, studies have shown that flaxseed can reduce oxidative damage, including in MS patients (Pilar and others ; Zuravski and others ). However, some studies attribute these effects to FO and its high ALA concentration (Karaka and Eraslan ; Badawy and others ), whereas other studies indicate that the antioxidant effects of flaxseed are due to the presence of its lignans, especially SDG (Hu and others ; Newary and Abdou ).…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Flaxseed Oil and Flaxseed Lignan Secoisolariciresinol Diglucoside Against Oxidative Stress in Rats with Metabolic Syndrome

Pilar

Güllich

Oliveira

et al. 2017

Journal of Food Science

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We report that the antioxidant effects attributed to flaxseed are mainly due to its high lignan content, especially that of secoisolariciresinol diglucoside. This is significant because suggests that this compound can be used in isolation to prevent oxidative stress associated with MS. Furthermore, this study was the only one to perform a comparison of the abilities of 2 components of flaxseed to protect against oxidative stress in an MS model, which brings a great advance in the medicine's field, since it indicates another alternative for improve the health and the quality of life of patients with this disorder.

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Section: Introductionmentioning

confidence: 99%

Protective Role of Flaxseed Oil and Flaxseed Lignan Secoisolariciresinol Diglucoside Against Oxidative Stress in Rats with Metabolic Syndrome

Pilar

Güllich

Oliveira

et al. 2017

Journal of Food Science

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“…In this period, rapid variation in physiologic reactions is critical (Basoglu and Sevinc 2004). The examination of blood provides important data on the metabolic profile (Pilar et al 2014). This profile may vary according to area, animal's breed, milk yield, lactation period and nutrition (Taylor et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of antioxidant vitamins (A, D, E) and trace elements (Cu, Mn, Se, Zn) on some metabolic and reproductive profiles in dairy cows during transition period

Omur¹,

Kirbaş²,

Aksu³

et al. 2016

Polish Journal of Veterinary Sciences

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The objective of this study was to determine the effects of some antioxidant vitamins and trace elements on some metabolic and postpartum reproductive profiles in dairy cows during transition period. In the study, altogether 20 clinically healthy Brown Swiss dairy cows (aged 4-5 years-old) under the same management and feeding conditions in periparturient period were used. The animals were divided into two equal groups: control (C) and treatment (T) group (n=10 for each group). Vitamins (A, D, E) and trace elements (Cu, Mn, Se, Zn) were administered intramuscularly into the cows of the T group, while isotonic saline, as placebo, was injected subcutaneously into those in the C group. Blood samples were collected by venipuncture of the jugular vein at the beginning of transition period, parturition and 3-weeks after the parturition. The metabolic and reproductive parameters were determined. In the C group, statistically significant changes were observed in the levels of non-esterified fatty acids (NEFA), high density lipoprotein (HDL), low density lipoprotein (LDL), total protein (TP) (p<0.05), glucose (GLU), progesterone (P 4 ) (p<0.01), total cholesterol (T.CHOL), triglycerides (TG), UREA, creatinine (CRSC) and total bilirubin (TBIL) (p<0.001). In the T group, significant changes in the levels of NEFA, TBIL (p<0.05), T.CHOL, HDL, LDL (p<0.01), TG, GLU, P 4 , TAC and TOC (p<0.001) were observed. It was concluded that the administration of various vitamins and trace elements could be effective to improve some metabolic and reproductive profiles in dairy cows during the transition period.

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“…Health benefits of polyphenols are attributed to their strong antioxidant activity (Manach et al, 2004). Flaxseed is the richest source of polyphenols, secoisolariciresinol diglucoside (SDG, up to 3.7 g/ kg dry weight) (Manach et al, 2004), and studies have found health benefits of flaxseed (Pilar et al, 2014;Rhee & Brunt, 2011;Wang et al, 2015). Flaxseed SDG is metabolised into enterolactone (EL) by bacteria in the gut, and both SDG and EL have antioxidant activities that lower ROS induced oxidative damages (Hu, Yuan, & Kitts, 2007;Kitts et al, 1999;Prasad, 2000).…”

Section: Introductionmentioning

confidence: 99%

Flaxseed secoisolariciresinol diglucoside and enterolactone down-regulated epigenetic modification associated gene expression in murine adipocytes

Rhee

2016

Journal of Functional Foods

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28-days dietary supplementation with golden flaxseed improves biochemical and oxidative parameters in patients with metabolic syndrome

Cited by 20 publications

References 67 publications

Protective Role of Flaxseed Oil and Flaxseed Lignan Secoisolariciresinol Diglucoside Against Oxidative Stress in Rats with Metabolic Syndrome

Protective Role of Flaxseed Oil and Flaxseed Lignan Secoisolariciresinol Diglucoside Against Oxidative Stress in Rats with Metabolic Syndrome

Effects of antioxidant vitamins (A, D, E) and trace elements (Cu, Mn, Se, Zn) on some metabolic and reproductive profiles in dairy cows during transition period

Flaxseed secoisolariciresinol diglucoside and enterolactone down-regulated epigenetic modification associated gene expression in murine adipocytes

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