290 Effect of fermented mackerel oil on the hair growth

Kang, Jung Sook; Park, J.; Yoon, Hoon-Seok; Hyun, Yu Jae; Kim, S.; Ahn, Yoo-Bok; Yoo, Eun Sook; Kang, Hyun-Sil

doi:10.1016/j.jid.2017.07.288

Journal of Investigative Dermatology

2017

DOI: 10.1016/j.jid.2017.07.288

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290 Effect of fermented mackerel oil on the hair growth

Jung Sook Kang

J. Park

Hoon-Seok Yoon

et al.

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Rational Design of Human Hair Keratin−Driven Proteins for Hair Growth Promotion

Zhang,

Qing,

et al. 2024

Adv Healthcare Materials

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Keratins, the most abundant proteins in human hair, are excellent hair nutrients for growth. However, the complex components of keratin extract hinder their mechanism investigation, and the pure recombinant keratin with poor solubility limited its hair growth promotion efficiency. Here, the water−soluble recombinant keratins (RKs) of K31 and K81 are rationally designed through QTY Code methodology, which are then used to fabricate the microneedles to study the effect of keratin on hair growth. Interestingly, it is discovered that more than 40% of the hair follicles (HFs) in the RK81QTY group entered the anagen on day 12 and the diameter of new hair is 15.10 ± 2.45 µm, which significantly promoted growth and development of HFs and improved new hair quality compared to RK31QTY. Water‐soluble RKs significantly enhanced HFs activity and de novo regeneration of robust hairs compared to extract and minoxidil by upregulating the PI3K/AKT/Nf−κB signaling axis. These findings highlight the potential of designing solubilized recombinant keratins with distinct properties to improve therapeutical effects and open new avenues to designing keratin−based proteins.

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Rational Design of Human Hair Keratin−Driven Proteins for Hair Growth Promotion

Zhang,

Qing,

et al. 2024

Adv Healthcare Materials

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290 Effect of fermented mackerel oil on the hair growth

Cited by 1 publication

References 0 publications

Rational Design of Human Hair Keratin−Driven Proteins for Hair Growth Promotion

Rational Design of Human Hair Keratin−Driven Proteins for Hair Growth Promotion

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