291. efficacy of Rituximab and Plasma Exchange in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis With Severe Renal Disease

Pexivas

“…The histologic pattern was focal in 39 (19.6%), crescentic in 49 (24.6%), mixed in 73 (36.7%), and sclerotic in 38 (19.1%) patients. There were no differences in the distribution of the histologic categories in patients who received plasma exchange in comparison with the patients who did not receive plasma exchange (8). Only a minority of patients had kidney involvement not amenable to aggressive treatment.…”

“…The PLEX regimen was more aggressive than that of PEXIVAS and consisted of seven to 14 daily sessions. Plasma exchange had no effect on remission induction at 6 months and on progression to kidney failure or survival at 18 and 24 months (8).…”

Application of the ANCA Renal Risk Score in the United States: A Single-Center Experience

“…Up to 64-85% of patients with ANCA-associated vasculitis develop a crescentic glomerulonephritis (GN) with a histologic spectrum from early fibrinoid necrosis to global sclerosis. 1,2 Significant strides have been made in diagnosis and treatment of ANCA-associated vasculitis. A significant proportion of patients however progress to end stage kidney disease (ESKD) and often experience treatment related adverse effects, including infection.…”

“…Sam Kant, MD 1 , Francesca Costigliolo, MD 2,3 , Silke Brix, MBBS 4 , Paride Fenaroli, MD 2,5 , Avi Rosenberg, MD 2 , Duvuru Geetha, MBBS 1,6 Article Information J o u r n a l P r e -p r o o f…”

“…Authors' Full Names and Academic Degrees: Sam Kant, MD1 , Francesca Costigliolo, MD2,3 , Silke Brix, MBBS4 , Paride Fenaroli, MD2,5 , Avi Rosenberg, MD2 , Duvuru Geetha, MBBS1,6 5. Li AS, Saleh C, Denley H, Patel M, Brix SR. ANCA renal risk score predicts outcome in the Manchester cohort.…”