291 Limitations of ELISA inhibition as a measure of infra and inter generic cross-reactivity in the fungi

Aeroallergens of southeastern missouri, usa

“…By means of various immunochemical and biological methods, Agarwal et al (1982) showed that Altertiaria and a morphologically related Stettiphylliitnt extracts contain multiple shared allergenic and antigenic determinants, and that both extracts contained Ah-I as one of the major shared allergenic components. Ike et al (1983) using ELISA inhibition demonstrated strong cross reactivity ofAlfernnria with Sfetttphylliiini, Ciirvrrlaria, and Stachybottys, but not with Cladosporiirm. She suggested that while antigenic variability does exist between Alfertinria and related genera, common antigens and preparative variability may render RAST and ELISA inhibition assays of limited use, except where widely divergent taxa are concerned.…”