292P Evaluation of the cardioprotective effects of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy

Abstract

Background: Anthracycline-induced cardiotoxicity is the most common constraint of its use in the treatment of various types of cancer. This study aimed to investigate the benefits of adding L-carnitine and silymarin compared to anthracycline chemotherapy alone in patients with cancer.Methods: 83 patients were recruited from the Clinical Oncology Department, Tanta University, Egypt, and prospectively randomized to receive their anthracycline-containing therapeutic regimen, control group (n¼33), anthracycline plus L-carnitine, Lcarnitine group (n¼25), or anthracycline plus silymarin, silymarin group (n¼ 25). Blood samples were collected at begging and after 6 months to measure LDH, CK-MB, cTn I, Anticardiolipin IgG, Fe, ferritin, and TIBC, and % of saturation. % EF was documented. Data were statistically analyzed by ANOVA and paired t-test. P <0.05 was statistically significant. Results:The obtained data suggested that adding L-carnitine to anthracycline chemotherapy had a significant beneficial effect on %EF (p¼0.003), anticardiolipin IgG (P¼0.000), ferritin (P¼0.000) , and TIBC(P¼0.011) , and that adding silymarin to anthracycline chemotherapy had a significantly beneficial effect on anticardiolipin IgG (P¼0.000), iron (p¼0.001),ferritin (p¼ 0.000), TIBC (p¼0.007) , and % saturation (p¼0.001) silymarin group showed a significant decrease in iron profile compared to the L-carnitine group, supporting the hypothesis of silymarin iron chelating activity. Conclusions:The co-administration of L-carnitine or silymarin with anthracyclinecontaining chemotherapy represents a new therapeutic strategy, especially silymarin, for better control of anthracycline-induced cardiotoxicity, as silymarin resulted in more beneficial effects on iron profile compared to anthracycline alone and anthracycline with L-carnitine.Legal entity responsible for the study: The authors.

l-Carnitine Mitigates Trazadone Induced Rat Cardiotoxicity Mediated via Modulation of Autophagy and Oxidative Stress

“…l -carnitine (LC) (β-hydroxy-γ-N-trimethylaminobutyric acid) is required for the transport of long-chain fatty acids into mitochondrial matrix to start β-oxidation of fatty acids which is the primary energy source in the myocardium[ 10 ]. Previous studies demonstrated that LC has antioxidant, anti-inflammatory, and antiapoptotic properties which could be of value in protection against cardiotoxicity [ 11 , 12 ]. The purpose of this study was to investigate the molecular mechanisms that explain l- carnitine's protection against TRZ-induced cardiotoxicity by examining its effects on autophagy, inflammation, and oxidative stress.…”