2012
DOI: 10.1111/j.1538-7836.2011.04585.x
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2B or not 2B? Masquerading as von Willebrand disease?

Abstract: region associated with mild hemophilia A and resistance to DDAVP therapy. J Thromb Haemost 2009; 7: 1234-5. 13 Dai L, Cutler JA, Savidge GF, Mitchell MJ. Characterization of a causative mutation of hemophilia A identified in the promoter region of the factor VIII gene (F8 , this being the value most laboratories report using in surveys of practise [3,4], and also reflecting the current approved CLSI guideline [5]. However, it is recognized that some forms of 2B VWD, evidenced by mutational studies, may not sho… Show more

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Cited by 11 publications
(7 citation statements)
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“…Indeed, we recall seeing such a low level “false‐positive” (0.5 mg/mL) LD‐RIPA on only one other occasion in our experience, with this not being observed on repeat testing (i.e., was not reproducible) in that patient. However, ‘false positive’ events with responsiveness seen at 0.7, or less often at 0.6, mg/mL have occasionally been seen by us (as previously reported) . Alternatively, some patients with 2B‐VWD may not show evidence of enhanced RIPA or may only show RIPA positivity at concentrations higher than 0.5 mg/mL .…”
Section: Discussionsupporting
confidence: 53%
See 1 more Smart Citation
“…Indeed, we recall seeing such a low level “false‐positive” (0.5 mg/mL) LD‐RIPA on only one other occasion in our experience, with this not being observed on repeat testing (i.e., was not reproducible) in that patient. However, ‘false positive’ events with responsiveness seen at 0.7, or less often at 0.6, mg/mL have occasionally been seen by us (as previously reported) . Alternatively, some patients with 2B‐VWD may not show evidence of enhanced RIPA or may only show RIPA positivity at concentrations higher than 0.5 mg/mL .…”
Section: Discussionsupporting
confidence: 53%
“…Although RIPA hyperresponsiveness is a defining feature of 2B or PT‐VWD, samples will infrequently provide false positive results, as in our patient, or false negative results. RIPA is practically challenging to perform, requiring rapid testing of freshly collected blood, and establishment of local normal and “pathological” ranges, with potentially frequent changes in ristocetin batches .…”
Section: Discussionmentioning
confidence: 69%
“…17 The cutoff values of ristocetin concentration in RIPA can contribute to false-negative or false-positive results. 55 On the basis of our experience, it is necessary to perform the assay with decreasing ristocetin concentrations, until reaching the lowest concentration that causes aggregation. This may vary between patients, especially according to the VWF:RCo levels.…”
Section: Discussionmentioning
confidence: 99%
“…The clinical diagnosis challenge stems from the close similarity of PT-VWD to the more common bleeding disorder, type 2B VWD. 2,3 The discrimination and correct diagnosis can only be made after carefully assessing less commonly performed laboratory tests, [3][4][5][6][7][8] and confirmed only after DNA analysis of the binding regions in the two genes VWF and GP1BA 9 has been performed.…”
mentioning
confidence: 99%