2BA The interval between primary melanoma excision and sentinel node biopsy (SNB) does not affect survival; regardless of SNB status - an EORTC Melanoma Group study

Instroduction In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumor and sentinel-node biopsy. The objective of this study is to analyze the prognostic implications of this delay. Patients and method This was an observational, retrospective, cohort study in four tertiary referral hospitals. A total of 1963 patients were included. The factor of interest was the interval between the date of the excisional biopsy of the primary melanoma and the date of the sentinel-node biopsy (delay time) in the prognosis. The primary outcome was melanoma-specific survival and disease-free survival. Results A delay time of 40 days or less (HR, 1.7; CI, 1.2 to 2.5) increased Breslow thickness (Breslow ≥2 mm, HR >3.7; CI 1.4 to 10.7), ulceration (HR 1.6; CI, 1.1 to 2.3), sentinel-node metastasis (HR, 2.9; CI, 1.9 to 4.2), and primary melanoma localized in the head or neck were independently associated with worse melanoma-specific survival (all P<0.03). The stratified analysis showed that the effect of delay time was at the expense of the patients with a negative sentinel-node biopsy and without regression. Conclusion Early sentinel-node biopsy is associated with worse survival in patients with cutaneous melanoma.

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Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma

Tejera‐Vaquerizo

Nagore

Puig

et al. 2015

European Journal of Cancer

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2BA The interval between primary melanoma excision and sentinel node biopsy (SNB) does not affect survival; regardless of SNB status - an EORTC Melanoma Group study

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Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma

Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma

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