2D Black Phosphorus-Based Cytomembrane Mimics with Stimuli-Responsive Antibacterial Action Inspired by Endotoxin-Associated Toxic Behavior

Abstract

Biomimetic membrane materials have been widely explored and developed for drug loading and tissue engineering applications due to their excellent biocompatibility and abundant reaction sites. However, novel cytomembrane mimics have been lacking for a long time. In this study, black phosphorus (BP) was used as the foundation for a new generation of promising cytomembrane mimics due to its multiple similarities to cytomembranes. Inspired by the dual function of endotoxins on membranes, we prepared a BP-based cytomembrane mimic with controllable antibacterial ability via electrostatic interaction between BP and [1-pentyl-1-quaternary ammonium-3-vinyl-imidazole]Br ([PQVI]­Br). The release of PQVI could be manipulated in different conditions by adjusting the electrostatic force, thereby achieving controllable antibacterial ability. This report confirms the possibility of using BP as a new material to mimic cytomembranes and provides a new concept of controllable antibacterial action based on endotoxins.

2D Nanomaterials from Group VA Single-element: Research Progress in Biomedical Fields

“…作为二维纳米材料家族的新成员, 具有可调带 隙和高电荷载流子迁移率的黑磷在微电器件、光电 器件、能源和催化剂等诸多领域中具有广阔的应用 前景。黑磷由于毒性较低, 表面积较大, 物理、化学 和生物活性优异 [21][22] , 在生物医学方面的应用亦成 为 研 究 热 点 , 包 括 生 物 传 感 [23][24][25] 、 光 热 疗 法 (Photothermal Therapy, PTT)/光动力学疗法(Photo-dynamic Therapy, PDT) [6,[8][9][10] 、药物控制释放 [26] 和抗 菌用途 [27][28][29] 等。…”

Black Phosphorus-Based Dynamic Self-Healing Hydrogel to Integrate Demineralized Bone Matrix and Noggin-Targeting siRNA for Synergistic Osteogenesis

“…Numerous nanomaterials have been explored for biomedical applications, such as drug delivery, tissue regeneration, biosensing, and diagnosis. − Black phosphorus (BP), a 2D nanomaterial, has attracted the attention of researchers from a wide range of fields due to its distinctive atomic structure arrangement and remarkable physical-optical properties. − BP has demonstrated its significant application potential in biomedical fields, particularly in cancer therapy, bioimaging, and drug delivery, benefiting from its inherent biocompatibility, large specific surface area, and exceptional near-infrared light photothermal/photoelectric conversion efficiency. − BP is a promising gene delivery vehicle since it can spontaneously degrade in response to the intracellular microenvironment. , Most significantly, the degradation products of BP are phosphate/phosphite, which can spontaneously combine with Ca 2+ to form CaP nanoparticles in the physiological environment, leading to in situ biomineralization . Given this unique property, BP has been used in various bone conduction materials.…”

“…20−23 BP is a promising gene delivery vehicle since it can spontaneously degrade in response to the intracellular microenvironment. 24,25 Most significantly, the degradation products of BP are phosphate/phosphite, which can spontaneously combine with Ca 2+ to form CaP nanoparticles in the physiological environment, leading to in situ biomineralization. 26 Given this unique property, BP has been used in various bone conduction materials.…”

Quaternary Ammonium Compounds and Their Composites in Antimicrobial Applications

“…[9][10][11] Therefore, current research has focused on the controlled release of QACs to diminish their overall utilization without sacrificing the antimicrobial performance. For instance, QAC composites (QACCs) can be engineered as stimuli-responsive systems for targeted QAC delivery at bacterial infection sites, [12][13][14] anchored covalently onto food packaging surfaces to minimize leakage, [15][16][17] and functionalized with targeting groups to mitigate harm to healthy tissues. [18,19] Hence, the development of QACCs offers a practical solution to address challenges associated with individual QACs and further broadens their applications.…”