2D carbon materials based photoelectrochemical biosensors for detection of cancer antigens

Tan, Adriel Yan Sheng; Lo, Newton Well; Cheng, Faliang; Zhang, Min; Tan, Michelle T.T.; Manickam, Sivakumar; Muthoosamy, Kasturi

doi:10.1016/j.bios.2022.114811

Cited by 36 publications

(10 citation statements)

References 193 publications

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“…Photoelectrochemical (PEC) bioanalysis is one of the state-of-the-art bioanalytical methods with excellent characteristics in terms of light input and background reduction. − However, sometimes the use of conventional PEC analysis for the detection of low content of the target can result in poor sensitivity, which is not conducive to the search for optimal potential. Organic electrochemical transistor (OECT) biosensors are excellent candidates for biosensing applications due to their good biocompatibility, structural flexibility, and intrinsic amplification .…”

Section: Introductionmentioning

confidence: 99%

MXene-Enhanced Bi₂S₃/CdIn₂S₄ Heterojunction Photosensitive Gate for DEHP Detection in a Signal-On OPECT Aptamer Biosensor

Zhang,

et al. 2024

Anal. Chem.

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Organic electrochemical transistors with signal amplification and good stability are expected to play a more important role in the detection of environmental pollutants. However, the bias voltage at the gate may have an effect on the activity of vulnerable biomolecules. In this work, a novel organic photoelectrochemical transistor (OPECT) aptamer biosensor was developed for di(2-ethylhexyl) phthalate (DEHP) detection by combining photoelectrochemical analysis with an organic electrochemical transistor, where MXene/Bi 2 S 3 /CdIn 2 S 4 was employed as a photoactive material, target-dependent DNA hybridization chain reaction was used as a signal amplification unit, and Ru(NH 3 ) 63+ was selected as a signal enhancement molecule. The poly(3,4ethylenedioxythiophene):poly(styrenesulfonate)-based OPECT biosensor modulated by the MXene/Bi 2 S 3 /CdIn 2 S 4 photosensitive material achieved a high current gain of nearly a thousand times at zero bias voltage. The developed signal-on OPECT sensing platform realized sensitive and specific detection of DEHP, with a detection range of 1−200 pM and a minimum detection limit of 0.24 pM under optimized experimental conditions, and its application to real water samples was also evaluated with satisfactory results. Hence, the construction of this OPECT biosensing platform not only provides a promising tool for the detection of DEHP but also reveals the great potential of the OPECT application for the detection of other environmental toxins.

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Section: Introductionmentioning

confidence: 99%

MXene-Enhanced Bi₂S₃/CdIn₂S₄ Heterojunction Photosensitive Gate for DEHP Detection in a Signal-On OPECT Aptamer Biosensor

Zhang,

et al. 2024

Anal. Chem.

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“…[69][70][71][72][73] This ease and compatibility of functionalization, combined with their intrinsic properties, make carbon nanomaterials uniquely suited for biosensing applications. [74] The high tunability of the surface chemistry for carbon nanomaterials enables them to be specific with target biomolecules, further enhancing their sensitivity and selectivity as diagnostic tools. [75,76] Carbon-based nanostructures have been extensively employed in biosensors and therapy fields, [77][78][79] which are essential for food, agriculture, and environmental monitoring applications.…”

Section: Introductionmentioning

confidence: 99%

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Britto,

Guan,

Tran

et al. 2024

Small Science

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Despite significant advancements in medical technology, cancer remains the world's second‐leading cause of death, largely attributed to late‐stage diagnoses. While traditional cancer detection methodologies offer foundational insights, they often lack the specificity, affordability, and sensitivity for early‐stage identification. In this context, the development of biosensors offers a distinct possibility for the precise and rapid identification of cancer biomarkers. Carbon nanomaterials, including graphene, carbon nitride, carbon quantum dots, and other carbon‐based nanostructures, are highly promising for cancer detection. Their simplicity, high sensitivity, and cost‐effectiveness contribute to their potential in this field. This review aims to elucidate the potential of emerging carbon‐nanomaterial‐based biosensors for early cancer diagnosis. The relevance of the various biosensor mechanisms and their performance to the physicochemical properties of carbon nanomaterials is discussed in depth, focusing on demonstrating broad methodologies for creating performance biosensors. Diverse carbon‐nanomaterial‐based detection techniques, such as electrochemical, fluorescence, surface plasmon resonance, electrochemiluminescence, and quartz crystal microbalance, are emphasized for early cancer detection. At last, a summary of existing challenges and future outlook in this promising field is elaborated.

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“…The photoelectrochemistry (PEC) method is an analytical tool that has the potential to reach the sensitivity of chemiluminescence and electrochemiluminescence measurements [ 13 , 14 ]. In this technique, light and electricity are used as excitation and signal detection sources, respectively [15] , [16] , [17] .…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 detection enabled by a portable and label-free photoelectrochemical genosensor using graphitic carbon nitride and gold nanoparticles

Catunda

Prado

Oliveira

et al. 2023

Electrochimica Acta

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2D carbon materials based photoelectrochemical biosensors for detection of cancer antigens

Cited by 36 publications

References 193 publications

MXene-Enhanced Bi₂S₃/CdIn₂S₄ Heterojunction Photosensitive Gate for DEHP Detection in a Signal-On OPECT Aptamer Biosensor

MXene-Enhanced Bi₂S₃/CdIn₂S₄ Heterojunction Photosensitive Gate for DEHP Detection in a Signal-On OPECT Aptamer Biosensor

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

SARS-CoV-2 detection enabled by a portable and label-free photoelectrochemical genosensor using graphitic carbon nitride and gold nanoparticles

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2D carbon materials based photoelectrochemical biosensors for detection of cancer antigens

Cited by 36 publications

References 193 publications

MXene-Enhanced Bi2S3/CdIn2S4 Heterojunction Photosensitive Gate for DEHP Detection in a Signal-On OPECT Aptamer Biosensor

MXene-Enhanced Bi2S3/CdIn2S4 Heterojunction Photosensitive Gate for DEHP Detection in a Signal-On OPECT Aptamer Biosensor

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

SARS-CoV-2 detection enabled by a portable and label-free photoelectrochemical genosensor using graphitic carbon nitride and gold nanoparticles

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MXene-Enhanced Bi₂S₃/CdIn₂S₄ Heterojunction Photosensitive Gate for DEHP Detection in a Signal-On OPECT Aptamer Biosensor

MXene-Enhanced Bi₂S₃/CdIn₂S₄ Heterojunction Photosensitive Gate for DEHP Detection in a Signal-On OPECT Aptamer Biosensor