2D layered nanomaterials for therapeutics delivery

Davis, Ryan; Urbanowski, Richard A.; Gaharwar, Akhilesh K.

doi:10.1016/j.cobme.2021.100319

Cited by 26 publications

(17 citation statements)

References 112 publications

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“…Microspheres are desirable for delivery applications due to their ease of injection, targeting ability, and scalability (Vigata et al, 2020;Yawalkar et al, 2022). NS has only recently been explored for biomedical applications, including delivery (Cross et al, 2019;Gaharwar et al, 2019;Davis et al, 2021). The facile incorporation of NS into the polymer matrix and enhancement of microsphere mechanical properties enables a unique and versatile delivery platform for localized release (Zhang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Nanosilicate-hydrogel microspheres formed by aqueous two-phase separation for sustained release of small molecules

Dharmesh

Stealey

Salazar

et al. 2023

Front. Biomater. Sci.

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Introduction: Hydrogel microspheres are an attractive option for drug delivery applications due to their ease of injection and potential for tunable controlled delivery. However, their utility is limited due to high initial burst release and rapid overall release, which is especially pronounced for small molecules or small size microspheres. We and others have shown that the addition of two-dimensional nanosilicate (NS) particles to hydrogels can significantly prolong release kinetics from hydrogels while minimizing burst release.Materials and Methods: Here we explored whether NS could modulate release kinetics of small molecules from small size injectable microspheres. Polyethylene glycol (PEG)-based hydrogel microspheres were fabricated via polymer/salt aqueous two-phase separation (ATPS), which is facile, high yield, and scalable, without the need for organic solvents or oils.Results and Discussion: Importantly, NS and acridine orange (AO), a model cationic small molecule, were shown to phase separate into the PEG-rich phase, allowing for successful encapsulation within hydrogel microspheres. The fabricated microspheres were stable, similar in size to red blood cells, and easily injectable. The effect of various fabrication parameters, including the addition of NS and AO, on microsphere size and polydispersity were explored. Release of AO was significantly slowed from PEG-NS microspheres compared to PEG-only microspheres and correlated with NS concentration. Two additional small molecules, the chemotherapeutic doxorubicin (positive charge), and the model small molecule Brilliant Blue FCF (negative charge), were shown to exhibit prolonged release, underscoring the broad utility of the system. The dependence of release kinetics on encapsulated NS concentration allows for tunable and prolonged release of small molecules from an injectable hydrogel delivery device.

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Section: Discussionmentioning

confidence: 99%

Nanosilicate-hydrogel microspheres formed by aqueous two-phase separation for sustained release of small molecules

Dharmesh

Stealey

Salazar

et al. 2023

Front. Biomater. Sci.

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“…Mxene is a layered two-dimensional transition metal material, including transition metal carbide, nitride and carbonitride, expressed as M n + 1 X n , where M is a transition metal, such as Ti or Nb, and X is carbon and/or nitrogen [ 124 ]. Mxene nanosheets have also been widely studied in the biomedical field due to their unique chemical and physical properties, such as electrical conductivity, photothermal conversion ability, and drug loading ability.…”

Section: Mussel-inspired 2d Nanomaterials-loaded Hydrogelsmentioning

confidence: 99%

Advances of Mussel-Inspired Nanocomposite Hydrogels in Biomedical Applications

Qiao

Han

2023

Biomimetics

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Hydrogels, with 3D hydrophilic polymer networks and excellent biocompatibilities, have emerged as promising biomaterial candidates to mimic the structure and properties of biological tissues. The incorporation of nanomaterials into a hydrogel matrix can tailor the functions of the nanocomposite hydrogels to meet the requirements for different biomedical applications. However, most nanomaterials show poor dispersion in water, which limits their integration into the hydrophilic hydrogel network. Mussel-inspired chemistry provides a mild and biocompatible approach in material surface engineering due to the high reactivity and universal adhesive property of catechol groups. In order to attract more attention to mussel-inspired nanocomposite hydrogels, and to promote the research work on mussel-inspired nanocomposite hydrogels, we have reviewed the recent advances in the preparation of mussel-inspired nanocomposite hydrogels using a variety of nanomaterials with different forms (nanoparticles, nanorods, nanofibers, nanosheets). We give an overview of each nanomaterial modified or hybridized by catechol or polyphenol groups based on mussel-inspired chemistry, and the performances of the nanocomposite hydrogel after the nanomaterial’s incorporation. We also highlight the use of each nanocomposite hydrogel for various biomedical applications, including drug delivery, bioelectronics, wearable/implantable biosensors, tumor therapy, and tissue repair. Finally, the challenges and future research direction in designing mussel-inspired nanocomposite hydrogels are discussed.

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“…Characterized with an ultrathin, layered structure and high surface-to-volume ratio, enabling high loading of various therapeutics, 2D-NMs sustain a prolonged release at the target site, whereby some 2D nanocarriers can provide on-demand therapeutic release, as a response to external stimuli. For medicinal use, the 2D nanocarriers, which are biocompatible and degrade into nontoxic products, are favorable [ 83 ]. These 2D materials possess important properties, such as semiconductivity, high surface area, a chemical nature suitable to be functionalized or decorated, and a stable structure and targeting ability, which can ensure a controlled and sustained release of drugs; these materials can also be used for thermal-based therapies, which predestine them to be applied in cancer therapy [ 84 ].…”

Section: Gbns As Drugs and Nanocarriersmentioning

confidence: 99%

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

Jampílek

Kráľová

2022

IJMS

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Climate change and increasing contamination of the environment, due to anthropogenic activities, are accompanied with a growing negative impact on human life. Nowadays, humanity is threatened by the increasing incidence of difficult-to-treat cancer and various infectious diseases caused by resistant pathogens, but, on the other hand, ensuring sufficient safe food for balanced human nutrition is threatened by a growing infestation of agriculturally important plants, by various pathogens or by the deteriorating condition of agricultural land. One way to deal with all these undesirable facts is to try to develop technologies and sophisticated materials that could help overcome these negative effects/gloomy prospects. One possibility is to try to use nanotechnology and, within this broad field, to focus also on the study of two-dimensional carbon-based nanomaterials, which have excellent prospects to be used in various economic sectors. In this brief up-to-date overview, attention is paid to recent applications of graphene-based nanomaterials, i.e., graphene, graphene quantum dots, graphene oxide, graphene oxide quantum dots, and reduced graphene oxide. These materials and their various modifications and combinations with other compounds are discussed, regarding their biomedical and agro-ecological applications, i.e., as materials investigated for their antineoplastic and anti-invasive effects, for their effects against various plant pathogens, and as carriers of bioactive agents (drugs, pesticides, fertilizers) as well as materials suitable to be used in theranostics. The negative effects of graphene-based nanomaterials on living organisms, including their mode of action, are analyzed as well.

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2D layered nanomaterials for therapeutics delivery

Cited by 26 publications

References 112 publications

Nanosilicate-hydrogel microspheres formed by aqueous two-phase separation for sustained release of small molecules

Nanosilicate-hydrogel microspheres formed by aqueous two-phase separation for sustained release of small molecules

Advances of Mussel-Inspired Nanocomposite Hydrogels in Biomedical Applications

Advances in Biologically Applicable Graphene-Based 2D Nanomaterials

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