2D materials and van der Waals heterostructures platforms for advanced sensing of COVID-19

Quintana, Mildred

doi:10.1016/b978-0-323-90248-9.00015-2

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…[ 13 ] It is reported that 2D material van der Waals (vdW) heterostructures allow adjusting the interfacial phenomena for the tailored design of the sensing mechanism. [ 14 ] In our case, MXene‐graphene heterostructure thin film provides improved band gap compared with pure graphene and improved electron mobility compared with pure MXene, which are suggested by numerous literatures for high‐efficiency FET sensing. [ 10,15 ] Moreover, MXenes are flakes in micro scale and need continuous graphene as the substrate.…”

Section: Introductionmentioning

confidence: 72%

Wearable MXene‐Graphene Sensing of Influenza and SARS‐CoV‐2 Virus in Air and Breath: From Lab to Clinic

Li,

Peng,

et al. 2023

Adv Materials Technologies

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The rapidly expanding severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its variants demand a continuous monitoring method through portable and wearable devices. Utilizing the rich surface chemistry and high chemical‐to‐electrical signal conversion of 2D MXene‐graphene heterostructure thin films, a field‐effect‐transistor (FET) sensor, which has a flexible substrate to be assembled onto the mask and combines with a Bluetooth system for wireless transmission is developed, to detect the influenza and SARS‐CoV‐2 viruses in air and breath. At first, the developed sensors are examined in the laboratory through direct contact with sensing targets in solution form. The results show a low limit of detection (LOD) of 1 fg mL−1 for recombinant SARS‐CoV‐2 spike protein and 125 copies mL−1 for inactivated influenza A (H1N1) virus with high specificity in differing recombinant SARS‐CoV‐2 spike protein and inactivated H1N1 virus. Then the sensors are tested under various simulated human breathing modes through controlled exposure to atomizer‐generated aerosols in an enclosed chamber and mask coverage. The results show the high sensitivity of the developed sensors under varying distances to the source, viral load, flow rate, and enclosed conditions. At last, clinical tests are carried out to demonstrate the robustness and potential field applications of the sensors.

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Section: Introductionmentioning

confidence: 72%

Wearable MXene‐Graphene Sensing of Influenza and SARS‐CoV‐2 Virus in Air and Breath: From Lab to Clinic

Li,

Peng,

et al. 2023

Adv Materials Technologies

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“…Emerging viruses, such as COVID-19, responsible for the pandemic that emerged in 2019 in Wuhan, China, highlighted the importance of the fast and simple development of innovative biosensors. The 2D materials properties allowed the fabrication of COVID-19 biosensors with high sensitivity [ 43 ]. Peng and collaborators [ 44 ] used carboxyl functionalized MoS 2 deposited on ITO to identify SARS-CoV-2 and its S protein by n-IR plasmonic response at 1550 nm.…”

Section: Biosensorsmentioning

confidence: 99%

Chemically Functionalized 2D Transition Metal Dichalcogenides for Sensors

Acosta,

Quintana

2024

Sensors

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The goal of the sensor industry is to develop innovative, energy-efficient, and reliable devices to detect molecules relevant to economically important sectors such as clinical diagnoses, environmental monitoring, food safety, and wearables. The current demand for portable, fast, sensitive, and high-throughput platforms to detect a plethora of new analytes is continuously increasing. The 2D transition metal dichalcogenides (2D-TMDs) are excellent candidates to fully meet the stringent demands in the sensor industry; 2D-TMDs properties, such as atomic thickness, large surface area, and tailored electrical conductivity, match those descriptions of active sensor materials. However, the detection capability of 2D-TMDs is limited by their intrinsic tendency to aggregate and settle, which reduces the surface area available for detection, in addition to the weak interactions that pristine 2D-TMDs normally exhibit with analytes. Chemical functionalization has been proposed as a consensus solution to these limitations. Tailored surface modification of 2D-TMDs, either by covalent functionalization, non-covalent functionalization, or a mixture of both, allows for improved specificity of the surface–analyte interaction while reducing van der Waals forces between 2D-TMDs avoiding agglomeration and precipitation. From this perspective, we review the recent advances in improving the detection of biomolecules, heavy metals, and gases using chemically functionalized 2D-TMDs. Covalent and non-covalent functionalized 2D-TMDs are commonly used for the detection of biomolecules and metals, while 2D-TMDs functionalized with metal nanoparticles are used for gas and Raman sensors. Finally, we describe the limitations and further strategies that might pave the way for miniaturized, flexible, smart, and low-cost sensing devices.

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