2D Materials-Based Fiber Optic SPR Biosensor for Cancer Detection at 1550 nm

Kaur, Baljinder; Kumar, Santosh; Kaushik, Brajesh Kumar

doi:10.1109/jsen.2021.3110967

Cited by 82 publications

(18 citation statements)

References 35 publications

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“…The increased amount of proteins in cancerous cells leads to an increase of 1.37 to 1.40 in their refractive index, a parameter that can be easily monitored through optical biosensors for early detection of cancer. One approach described the use of 2D materials-based fiber-optic surface plasmon resonance (SPR) to monitor the angular shift and power loss of cancerous cells, thus distinguished from healthy cell lines [ 105 ]. Incorporation of different allotropes such as SnSe alongside a heterostructure of Blue P/MOS 2 has also been shown to support the increase in refractive index variations to include monitoring cancer cells directly in biological solutions, as reported for the detection of skin, cervical, blood, adrenal gland, and breast (type-1 and type-2) cancer with a maximum quality factor of 24.83 RIU −1 and detection accuracy of 0.54 deg −1 [ 106 ].…”

Section: Cellular Eventsmentioning

confidence: 99%

PC-12 Cell Line as a Neuronal Cell Model for Biosensing Applications

et al. 2022

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PC-12 cells have been widely used as a neuronal line study model in many biosensing devices, mainly due to the neurogenic characteristics acquired after differentiation, such as high level of secreted neurotransmitter, neuron morphology characterized by neurite outgrowth, and expression of ion and neurotransmitter receptors. For understanding the pathophysiology processes involved in brain disorders, PC-12 cell line is extensively assessed in neuroscience research, including studies on neurotoxicity, neuroprotection, or neurosecretion. Various analytical technologies have been developed to investigate physicochemical processes and the biosensors based on optical and electrochemical techniques, among others, have been at the forefront of this development. This article summarizes the application of different biosensors in PC-12 cell cultures and presents the modern approaches employed in neuronal networks biosensing.

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Section: Cellular Eventsmentioning

confidence: 99%

PC-12 Cell Line as a Neuronal Cell Model for Biosensing Applications

et al. 2022

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“…Additionally, there have been tremendous research and recent development of several biosensing techniques that can be used to screen biochemical markers for the prognosis, diagnosis and management of diseases 176 . These techniques utilize various sensing approaches, including optical 177 , plasmonic 178,179 , photonic 180 and nanoparticle-based 181 approaches. For instance, some bilirubin metabolic pathways are still controversial after nearly a century of research.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

70 years of bilirubin sensing: towards the point-of-care bilirubin monitoring in cirrhosis and hyperbilirubinemia

Ndabakuranye

Burchall

et al. 2022

Sens. Diagn.

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“…Cancer is a disease that causes the rapid and uncontrollable creation of abnormal cells, and soon, these abnormalities spread throughout the whole body and damage different body organs, including healthy tissue and valuable organs, finally resulting in death. Due to the leading causes of death being by various types of cancers worldwide, early detection has become essential for diagnosing these diseases [ 3 ]. Early detection of cancer means the detection of tumors in the early stages of its development, and it is expected that with this strategy, the process of recovery will advance [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive TiO2/Au/Graphene Layer-Based Surface Plasmon Resonance Biosensor for Cancer Detection

et al. 2022

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In this article, a hybrid TiO2/Au/graphene layer-based surface plasmon resonance (SPR) sensor with improved sensitivity and capability for cancer detection is presented. The finite element method (FEM) was used for numerical analysis. The proposed SPR biosensor was structured based on the angular analysis of the attenuated total reflection (ATR) method for the detection of various types of cancer using the refractive index component. The resonance angle shifted owing to the increment of normal and cancerous cells’ refractive index, which varied between 1.36 and 1.401 for six different types of normal and cancerous cells. According to numerical results, the obtained sensitivities for skin (basal), cervical (HeLa), adrenal gland (PC12), blood (Jurkat), and breast (MCF-7 and MDA-MB-231) cancer cells were 210 deg/RIU, 245.83 deg/RIU, 264.285 deg/RIU, 285.71 deg/RIU, 292.86 deg/RIU, and 278.57 deg/RIU, respectively. Furthermore, the detection accuracy (DA), figure of merits (FOM), and signal-to-noise ratio (SNR) were also obtained, with values of 0.263 deg−1, 48.02 RIU−1, and 3.84, respectively. Additionally, the distribution of the electric field and the propagation of the magnetic field for resonant and non-resonant conditions of the proposed structure were illustrated. It was found that an enhanced field was exhibited on the surface of the plasmonic material for resonant conditions. We also measured the penetration depth of 180 nm using decayed electric field intensity. Furthermore, the impact of using a TiO2/Au/graphene layer was demonstrated. We further conducted analyses of the effects of the thickness of the gold layer and the effects of additional graphene layers on overall sensitivities for six different types of cancer. The proposed TiO2/Au/graphene layered structure exhibited the highest overall sensitivity in terms of detecting cancerous cells from healthy cells. Moreover, the proposed sensor was numerically analyzed for a wide range of biological solutions (refractive index 1.33 –1.41), and the sensor linearity was calculated with a linear regression coefficient (R2) of 0.9858. Finally, numerical results obtained in this manuscript exhibited high sensitivity in comparison with previously reported studies.

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2D Materials-Based Fiber Optic SPR Biosensor for Cancer Detection at 1550 nm

Cited by 82 publications

References 35 publications

PC-12 Cell Line as a Neuronal Cell Model for Biosensing Applications

PC-12 Cell Line as a Neuronal Cell Model for Biosensing Applications

70 years of bilirubin sensing: towards the point-of-care bilirubin monitoring in cirrhosis and hyperbilirubinemia

Highly Sensitive TiO2/Au/Graphene Layer-Based Surface Plasmon Resonance Biosensor for Cancer Detection

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