2D modeling and preliminary in vitro investigation of a prototype high gradient magnetic separator for biomedical applications

Chen, Haitao; Kaminski, Michael; Rosengart, Axel J.

doi:10.1016/j.medengphy.2007.02.002

Cited by 23 publications

(16 citation statements)

References 29 publications

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“…Furthermore, we found that the collection efficiency decreases linearly with increasing flow rate. Linear behaviour was also observed by Chen et al [6]. At low flow rate increasing the channel length is inefficient, since the number of collected particles decreases with distance.…”

Section: Resultssupporting

confidence: 67%

Separation of magnetic particles in channel flows by BEM

Ravnik

Hriberšek

Vogel

et al. 2012

Proc Appl Math and Mech

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In-line separation of suspensions can become difficult in case of particles with comparable values of densities. For flows in micro devices in such cases gravitational settling is inefficient, and other separation techniques must be applied. In case of magneto active particles, the action of Kelvin magnetic force in a non-uniform magnetic field could be used in order to achieve a higher degree of particles separation. The contribution therefore deals with Euler-Lagrangian formulation of dilute two-phase flows. The Boundary element based computational algorithm solves the incompressible Navier-Stokes equations written in velocity-vorticity formulation. The non-uniform magnetic field is defined analytically for the case of a set of long thin wires. The particle trajectories are computed by applying the 4th order Runge-Kutta method. The computed test case consists of a narrow channel with laminar flow of suspension under Re = 1 − 10. Particle trajectories under the influence of a non-uniform magnetic field are computed for the case of magnetite and aluminium particles suspended in water. The efficiency of separation on basis of particle trajectories for different values of Re number and magnetic field strength is performed, clearly indicating superior separation of magneto active particles.

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Section: Resultssupporting

confidence: 67%

Separation of magnetic particles in channel flows by BEM

Ravnik

Hriberšek

Vogel

et al. 2012

Proc Appl Math and Mech

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“…two different fluid phases, were pumped into the two inlets, respectively: a) Phase 1 -Fluorescein sodium salt solution (employed as a coloring agent to distinguish the phases), (Scharlau) or human whole blood (explained below), and b) Phase 2 -deionized water or a mixture of ethylene glycol in water 50% v/v (PanReac AppliChem), that exhibits a density and viscosity values similar to human blood (1050 kg•m 3 and 4.1 cP at 20ºC). 51 For the mass transfer analysis, we employed a specific Phase 1 fluorescein solution (60 mg•L -1 , diffusion coefficient for fluorescein in water: 4.25•10 -6 cm 2 •s -1 ), 52 whereas deionized water was pumped into the phase 2 inlet. To study the possible migration of blood cells between the fluid phases, we prepared aqueous solution of nonmagnetic 6-8 µm polystyrene beads (Spherotech, Inc., catalog number HISP-60-2) at a concentration of 1 g•L -1 .…”

Section: Experimental Methodologymentioning

confidence: 99%

Computational modeling and fluorescence microscopy characterization of a two-phase magnetophoretic microsystem for continuous-flow blood detoxification

et al. 2018

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Magnetic beads can be functionalized to capture and separate target pathogens from blood for extracorporeal detoxification. The beads can be magnetically separated from a blood stream and collected into a coflowing buffer solution using a two-phase liquid-liquid continuous-flow microfluidic device in the presence of an external field. However, device design and process optimization, i.e. high bead recovery with minimum blood loss or dilution remain a substantial technological challenge. We introduce a CFD-based Eulerian-Lagrangian computational model that enables the rational design and optimization of such systems. The model takes into account dominant magnetic and hydrodynamic forces on the beads as well as coupled bead-fluid interactions. Fluid flow (Navier-Stokes equations) and mass transfer (Fick's law) between the coflowing fluids are solved numerically, while the magnetic force on the beads is predicted using analytical methods. The model is demonstrated via application to a prototype device and used to predict key performance metrics; degree of bead separation, flow patterns, and mass transfer, i.e. blood diffusion to the buffer phase. The impact of different process variables and parameters - flow rates, bead and magnet dimensions and fluid viscosities - on both bead recovery and blood loss or dilution is quantified for the first time. The performance of the prototype device is characterized using fluorescence microscopy and the experimental results are found to match theoretical predictions within an absolute error of 15%. While the model is demonstrated here for analysis of a detoxification device, it can be readily adapted to a broad range of magnetically-enabled microfluidic applications, e.g. bioseparation, sorting and sensing.

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“…Leaching tests performed according to the TCLP protocols showed that leached arsenic remained below 5 µg L −1 , i.e. three orders of magnitude lower than the permitted limit for non‐hazardous wastes (5 mg L −1 ) …”

Section: Resultsmentioning

confidence: 90%

“…A high‐gradient magnetic separator originally employed for biomedical applications was re‐designed to remove the magnetic nanoparticles from a continuously flowing dispersion. Its operation was optimized by computational fluid analysis.…”

Section: Methodsmentioning

confidence: 99%

“…three orders of magnitude lower than the permitted limit for non-hazardous wastes (5 mg L −1 ). 19 The environmental safety of the procedure should be guaranteed not only by proper inactivation of disposed nanoparticles but also by evaluating the potential risk in case of accidental release into an aqueous environment. To investigate biocompatibility of the As-loaded nanoparticles, the cell survival rate was examined with respect to a gill cell line derived from fish.…”

Section: Environmental Impact Of the Processmentioning

confidence: 99%

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Regeneration of arsenic spent adsorbents by Fe/MgO nanoparticles

Simeonidis

Martínez-Boubeta²,

Rivera-Gil

et al. 2017

J of Chemical Tech & Biotech

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BACKGROUND Over recent decades, there has been increasing global concern over public health impacts related to water pollution with arsenic. With the development of nanotechnology, nanomaterials are being proposed as alternative agents for water treatment. This study focuses on the use of core‐shell nanoparticles as secondary receptors able to operate under intense conditions and perform efficient yet environmentally friendly regeneration of conventional adsorbents. RESULTS Hybrid MgO‐coated Fe nanoparticles are proposed, optimized to achieve maximum arsenic uptake under a strong alkaline environment, such as the NaOH stream used to regenerate a typical oxy‐hydroxide adsorption column. The magnetic response of these nanocomposites enables their recovery and recirculation by means of an external magnetic field. A scalable laboratory continuous flow system was designed as a proof‐of‐concept to provide maximum efficiency of the recirculating nanoparticles, as well as complete reuse of the alkaline washing solution. A risk assessment scheme was conducted to evaluate the potential environmental impact of nanoparticle residues by testing the toxicity of arsenic‐loaded materials in RTgill‐W1 cells and their inertization into concrete building blocks. CONCLUSION The presented methodology illustrates a way to incorporate nanoparticles in water technology taking advantage of their surface activity and magnetic separation potential. © 2016 Society of Chemical Industry

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2D modeling and preliminary in vitro investigation of a prototype high gradient magnetic separator for biomedical applications

Cited by 23 publications

References 29 publications

Separation of magnetic particles in channel flows by BEM

Separation of magnetic particles in channel flows by BEM

Computational modeling and fluorescence microscopy characterization of a two-phase magnetophoretic microsystem for continuous-flow blood detoxification

Regeneration of arsenic spent adsorbents by Fe/MgO nanoparticles

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