2D Molecular Square Grid with Strong Blue Fluorescent Emission:  A Complex of Norfloxacin with Zinc(II)

Chen, Zhen-Feng; Xiong, Ren‐Gen; Zhang, Jing; Chen, Xue-Tai; You, Xiao‐Zeng

doi:10.1021/ic001470x

Cited by 185 publications

(77 citation statements)

References 50 publications

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“…Zinc(II) [1] and Iron(II) [2] representatives have been already reported. The title cadmium(II) compound is a two-dimensional coordination polymer in which the anion acts in a bridging mode (figure, top).…”

Section: Discussionmentioning

confidence: 98%

Crystal structure of poly[bis(norfloxacin)cadmium(II)], [Cd(C16H17FN3O3)2]n

Zhong¹,

Xu²,

Cui³

et al. 2008

Zeitschrift Für Kristallographie - New Crystal Structures

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C 32H34CdF2N6O6, monoclinic, P121/c1 (no. 14), a = 5.5308(6) Å, b = 22.298(2) Å, c = 13.519(1) Å, Source of materialA mixture of Cd(NO 3 ) 2 · 6H 2 O (0.07 g, 0.25 mmol), Norfloxacin (H-Norf, 0.16 g, 0.5 mmol), and water (12 ml) was stirred for 20 min in air. The mixture was then transferred to a 23 ml Teflonlined hydrothermal bomb. The bomb was kept at 443 K for 96 hours under autogenous pressure. Colorless single crystals of the title compound suitable for X-ray analysis were obtained from the reaction mixture.

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Section: Discussionmentioning

confidence: 98%

Crystal structure of poly[bis(norfloxacin)cadmium(II)], [Cd(C16H17FN3O3)2]n

Zhong¹,

Xu²,

Cui³

et al. 2008

Zeitschrift Für Kristallographie - New Crystal Structures

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“…Lomefloxacinisone representative of the quinolone family. Ingeneral, quinolones can form supramolecules with other compounds through charge transfer complex formation [2,3]. But there are no reports about crystal structures of LMFor forming supramoleculesw ith other organic molecules.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of bis(lomefloxacin) 1,4-benzenedicarboxylate dihydrate, (C17H19F2N3O3)2[C8H6O4] · 2H2O

Zhou¹,

Zhao²,

J.-X.³

2006

Zeitschrift Für Kristallographie - New Crystal Structures

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C 42 H 48 F 4 N 6 O 12 ,triclinic, P 1 (no. 2), a =9.534(2) Å, b =11.315(2) Å, c =11.327(2) Å, a =97.89(3)°, Source of materialThe title compound was preparedb yh ydrothermal method. A mixture of Zn(NO 3 ) 2 (0.25 mmol), lomefloxacin hydrochloride (LMF)( 0.50 mmol), 1,4-benzene-dicarboxylic acid (1,4-bdc, 0.50 mmol) and water (12 ml) was stirred for 20 min. The mixture was then transferredtoa23mlTeflon-lined autoclave and kept at 443 Kfor 72 hunder autogenous pressure. After the mixture had been allowedtocool to room temperature slowly. The targeted Zn 2+ complex was not synthesized. Colorless single crystals of the title compound suitable for X-ray analysis were obtained from the reaction mixture. DiscussionLomefloxacin( LMF)i sas ynthetic, broad-spectrum fluoroquinolone antibacterial agent. Itwas active against awide variety of aerobic gram-negative and gram-positive bacteria like norfloxacin [1]. Lomefloxacinisone representative of the quinolone family. Ingeneral, quinolones can form supramolecules with other compounds through charge transfer complex formation [2,3]. But there are no reports about crystal structures of LMFor forming supramoleculesw ith other organic molecules. Our interest has been directed toward the synthesis of ametal complex based on LMF. The asymmetric unit of the title compound consists of one LMF, one half of 1,4-benzenedicarboxylic acid and one water molecule. The structure has extensive intermolecular and intramolecular hydrogen bonds that consolidate athree-dimensional network.

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“…Since these functional groups are required for antibacterial activity, it could be anticipated that all of the quinolones could be interacting with metal ions (15) . Literature survey assembled a number of different complexation of quinolones (17)(18)(19) .…”

Section: Fig1 Structure Of Moxifloxacinmentioning

confidence: 99%

Synthesis, Characterization, Spectrofluorometric and Antibacterial Activity Studies of Moxifloxacin- Zirconium Complex

2012

Egypt. J. Chem.

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PECTROSCOPIC methods such as mass, FT-IR and nuclear ........magnetic resonance in combination with thermal analysis measurements were used to verify and describe the physicochemical properties of the synthesized moxifloxacin (MOX) Zirconium (IV) metal complex. The spectroscopic and elemental analysis data support the formation of the complex with the formula C 21 H 23 FN 3 O 4 Zr(H 2 O) 2 .0.5H 2 O. Results revealed that complexation between Zirconium (IV) and moxifloxacin exhibited significant increase in antibacterial activity especially against Gram negative organisms.In addition, a simple, rapid, reliable, and sensitive spectrofluorometric method is developed for the determination of MOX. The method depends on the chelation of MOX with zirconium (IV) to produce fluorescent chelate (MOX/ Zr). Different factors affecting the relative fluorescence intensity of the resulting chelate were studied and optimized. The relationship between the concentration and relative fluorescence intensity was rectilinear in the range of 0.1-4 µg/ml. The limits of detection and quantitation are 0.06 and 0.11 µg/ ml, respectively.At the optimum reaction conditions, the drug-metal chelate showed excitation maximum at 333 nm and emission maxima at 485nm. The developed method was applied successfully for the determination of the studied drug in its pharmaceutical dosage forms with a good precision and accuracy.

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2D Molecular Square Grid with Strong Blue Fluorescent Emission: A Complex of Norfloxacin with Zinc(II)

Cited by 185 publications

References 50 publications

Crystal structure of poly[bis(norfloxacin)cadmium(II)], [Cd(C16H17FN3O3)2]n

Crystal structure of poly[bis(norfloxacin)cadmium(II)], [Cd(C16H17FN3O3)2]n

Crystal structure of bis(lomefloxacin) 1,4-benzenedicarboxylate dihydrate, (C17H19F2N3O3)2[C8H6O4] · 2H2O

Synthesis, Characterization, Spectrofluorometric and Antibacterial Activity Studies of Moxifloxacin- Zirconium Complex

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