2D-Mueller-matrix tomography of optically anisotropic polycrystalline networks of biological tissues histological sections

Abstract

A new technique of Mueller-matrix mapping of the birefringent structure of biological preparations of human organs tissues is suggested. The algorithms of reconstruction of average values and magnitude of fluctuations of the phase (birefringence) and amplitude (dichroism) of optically anisotropic structure of myocardium and connective tissue component of the vaginal wall histological section are proposed. The magnitudes and ranges of changes in the statistical moments of the 1st-4th order that characterize the distribution of average values and magnitude of fluctuations of birefringence and dichroism of the myocardium and connective tissue of the vaginal tissues histological sections were determined. Joint studies of distributions of the characteristics of phase and amplitude of the anisotropy of myocardium and connective tissue component of the vaginal wall tissues of different states were performed. The cases of various necrotic changes in the myocardium and pathological conditions of the vagina wall (prolapse of the genitals) are examined. Balanced accuracy of the method of Mueller-matrix polarization-phase and diffuse tomography of optically anisotropic polycrystalline networks in the differentiation of necrotic and pathological changes in human organs is determined.

Diagnostics of Genital Endometriosis Using Methods of Polycrystalline Structure Polarization-Phase Introscopy

“…6. Алгоритмічно відтворено лінійне та циркулярне двопроменезаломлення і дихроїзм об'єктивно оцінюються в межах статистичного аналізуалгоритмічно визначаються центральні статистичні моменти 1-го -4-го порядків, які характеризують середнє, дисперсію, асиметрію та ексцес (гострота піку) мап фазової та амплітудної анізотропії біологічних препаратів органів людини [9][10][11][12][13][14][15][16].…”

Polarization-Singular Approach to Imaging Mueller-Matrix Polarimetry in the Differential Diagnosis of Histological Sections of Biopsy of Tumors of the Uterus and Prostate

“…In Figure 1 shows the optical scheme of Stokes polarimetry [14,15] of the coordinate distributions of the Mueller-matrix invariant f 44 , which characterizes the birefringence of histological sections of uterine tumours. The optical and metrological parameters of the Stokespolarimeter are presented in detail in a series of publications [14,15,[27][28][29][30][31][32]. Here we give a brief description of them, which is necessary for a better understanding of the further presentation of the experimental material.…”

“…The measurement of the integral degree of depolarization (Λ, %) of samples of histological sections of uterus tissue was carried out in the scheme of a standard Mueller-matrix polarimeter, the optical scheme of which is presented in [14,15,[27][28][29][30][31][32].…”

“…This approach provides the most complete information on the optical anisotropy of diagnostic objects. Several key strands of investigation have emerged, including: Mueller matrix polarimetry (MMP) [21][22][23][24] polar decomposition of Mueller matrices [25,26]; and two [27][28][29][30][31][32] dimensional Mueller matrix mapping (MMM) using various approximations [19,20,33].…”