Two-dimensional(2D) materials have received extensive attention in optoelectronics because of their unique characteristics. However, due to the extremely thin thickness of 2D materials, their optical absorption is limited. In recent years, researchers have used different effects and structures to enhance the optical absorption of 2D materials. Waveguide, as a device to guide and limit light propagation, has been integrated into photodetectors based on 2D materials, and most of them are applied in the infrared spectrum. This article reviews the development of waveguide-integrated photodetectors based on 2D materials, mainly in the infrared spectrum in recent years. Discussions mainly focus on the preparation of materials in waveguide-integrated photodetectors, the design and simulation of waveguide structures, and the research results and applications of waveguide-integrated photodetectors in recent years are summarized. Finally, the challenges and prospects of waveguide-integrated photodetectors are put forward and discussed.