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Abstract

ABSTRACT:Artemisia vulgaris leaves are known to have anectodatal evidence of antioxidant activity which can be of use as an anti -stress remedy. However, this claim is yet to be proven and no available data on its adaptogenic potential hence, this study aimed to determine the adaptogenic potential of Artemisia vulgaris leaf extract on male albino rats using acute restraint stress. Six male albino rats were used as test animals and were subdivided into the following: control group, untreated normal group, negative group, and three doses of the test solution [500mg/200g rat (T1), 250mg/200g rat (T2), and 150 mg/200g rat (T3)]. T3 rats exhibited the highest adaptogenic activity of -3,111.11% based on cholesterol levels and -1916.67% based on glucose levels. Moreover, glucose levels of T2 and T1 rats were -345.41% and -6.60%, respectively while for their cholesterol levels, T2 exhibited -277.78% and T1 exhibited -90.05%. The median effective dose of the test suspension based on cholesterol levels and glucose levels is 169.70 mg/200g rat and 151.81mg/200g rats, respectively. From this study, Artemisia vulgaris leaf extract has the potential protective effect against stress. Flavanoids, tannins and saponins in the leaf extract of Artemisia vulgaris were attributed for its adaptogenic activity.