3-(1,3-Dioxoisoindolin-2-yl)-N,N-dimethylpropan-1-ammonium perchlorate: Synthesis, crystal structure, docking study and in vitro anticancer activity against the human hepatomas cell line (Hep G2)

Reja, Sahin; Mukherjee, Deboshmita; Das, Purak; Kumar, Pranesh; Das, Rajesh Kumar

doi:10.1016/j.molstruc.2021.131006

Journal of Molecular Structure

2021

DOI: 10.1016/j.molstruc.2021.131006

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3-(1,3-Dioxoisoindolin-2-yl)-N,N-dimethylpropan-1-ammonium perchlorate: Synthesis, crystal structure, docking study and in vitro anticancer activity against the human hepatomas cell line (Hep G2)

Sahin Reja

Deboshmita Mukherjee

Purak Das³

et al.

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Cited by 7 publications

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DNA cleaver with improved phosphatase and cytotoxic activity of a series of N₂O‐based zinc(II) complexes

Mukherjee,

Sarkar,

Bakibillah

et al. 2024

Applied Organom Chemis

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Three new Zn(II) Schiff base complexes, [ZnLCl2] (1), [ZnLBr2] (2) and [ZnL(SCN)2] (3), have been synthesized by adding Zn(II) salts of chloride and bromide to a compartmental ligand with NNO donor prepared through the simple condensation of pyridine‐2‐carboxaldehyde and a substituted aniline. The complexes have been identified using standard physicochemical methods, and their solid‐state structures have been determined through single‐crystal X‐ray analysis. The phosphatase‐like activity of all three complexes has been investigated using 4‐NPP as the model substrate in a DMSO/water medium. Complex 1 exhibits the highest level of phosphatase activity. The reactivity trend shows that complex 1 > complex 2 > complex 3. A plausible mechanism and the causes underlying the activity trend have been explored through DFT study, ESI‐mass spectra and 31P experiments. Complex 1 shows promising potential for use in gene‐targeted therapeutics due to its remarkable performance in DNA digestion. The excellent DNA cleavage result of complex 1 has led to the investigation of its molecular docking interaction with the liver cancer 2 receptor to study its anti‐liver cancer activity. Furthermore, in vitro anticancer activity of complex 1 also shows excellent antiproliferative activity against hepatocellular carcinoma.

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DNA cleaver with improved phosphatase and cytotoxic activity of a series of N₂O‐based zinc(II) complexes

Mukherjee,

Sarkar,

Bakibillah

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

Mononuclear Zn(II) Complex Based on N2O Ligand Compartment: First Case to Detect Nitro Explosives

Mukherjee,

Sarkar,

Reja

et al. 2023

J Fluoresc

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Nanometal surface energy transfer (NSET) from biologically active heterocyclic ligands to silver nanoparticles induces enhanced antimicrobial activity against gram-positive bacteria

Sarkar,

Manna,

Adhikary

et al. 2024

Colloids and Surfaces B: Biointerfaces

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3-(1,3-Dioxoisoindolin-2-yl)-N,N-dimethylpropan-1-ammonium perchlorate: Synthesis, crystal structure, docking study and in vitro anticancer activity against the human hepatomas cell line (Hep G2)

Cited by 7 publications

References 46 publications

DNA cleaver with improved phosphatase and cytotoxic activity of a series of N₂O‐based zinc(II) complexes

DNA cleaver with improved phosphatase and cytotoxic activity of a series of N₂O‐based zinc(II) complexes

Mononuclear Zn(II) Complex Based on N2O Ligand Compartment: First Case to Detect Nitro Explosives

Nanometal surface energy transfer (NSET) from biologically active heterocyclic ligands to silver nanoparticles induces enhanced antimicrobial activity against gram-positive bacteria

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3-(1,3-Dioxoisoindolin-2-yl)-N,N-dimethylpropan-1-ammonium perchlorate: Synthesis, crystal structure, docking study and in vitro anticancer activity against the human hepatomas cell line (Hep G2)

Cited by 7 publications

References 46 publications

DNA cleaver with improved phosphatase and cytotoxic activity of a series of N2O‐based zinc(II) complexes

DNA cleaver with improved phosphatase and cytotoxic activity of a series of N2O‐based zinc(II) complexes

Mononuclear Zn(II) Complex Based on N2O Ligand Compartment: First Case to Detect Nitro Explosives

Nanometal surface energy transfer (NSET) from biologically active heterocyclic ligands to silver nanoparticles induces enhanced antimicrobial activity against gram-positive bacteria

Contact Info

Product

Resources

About

DNA cleaver with improved phosphatase and cytotoxic activity of a series of N₂O‐based zinc(II) complexes

DNA cleaver with improved phosphatase and cytotoxic activity of a series of N₂O‐based zinc(II) complexes