3-((±)-2-Carboxypiperazin-4-yl)propyl-1-phosphonic acid (CCP) and phencyclidine produce a deficit of passive avoidance retention in rats

Functional interaction of NMDA and group I metabotropic glutamate receptors in negatively reinforced learning in rats

“…It was previously shown that MPEP did not influence sensitization of startle response induced by foot shocks (Schulz et al 2001). Similar findings were observed after administration of NMDA receptor antagonists, showing that there is no change in reaction to foot shock (Danysz et al 1988;DeNoble et al 1990) and that they do not induce antinociceptive effects in acute pain tests (Nishiyama 2000;Gould et al 2002). However, data on acute pain after coadministration of group I metabotropic and NMDA receptor antagonists have not been available.…”

Pharmacological studies of a rat spatial delayed nonmatch‐to‐sample task as an animal model of dementia

“…The NMDA receptor has been studied in relation to long-term potentiation (LTP), which is widely considered as a model for the neural basis of learning and memory [Collingridge and Bliss, 19871 and has been implicated in ischaemic or anoxic neuronal damage [Rothman and Olney, 19871. NMDA antagonists have been shown to disrupt performance in behavioural models such as the radial arm maze, Morris water maze, and passive avoidance [Benvenga and Spaulding, 1988;Butelman;Danysz et al, 1988;DeNoble et al, 1990;Heale and Harley, 1990;Ward et al, 19901. Particularly relevant to the present results, CPP and MK-801 have been reported to disrupt a delayed conditional discrimination in rats [Tan et al, 19891.…”

Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats

“…The former is more likely to cause nonspecific behavioral suppression, while specific cognitive deficits are more reliably observed after the latter (for review, see Jentsch and Roth 1999). A single PCP administration disrupts easy tasks dependent on simple sensory processes and associative learning (which are relatively spared in schizophrenia patients; Kesner et al 1983;Tang and Franklin 1983;Tang and Ho 1988;DeNoble et al 1990;Jones et al 1990) and produces motivational deficits that may confound cognitive test results (Frederick et al 1995). A number of studies have detected cognitive deficits after a single PCP injection (Danysz et al 1988;Sanger and Jackson 1989;Sanger 1992;Compton et al 2001;Le Pen et al 2003;Jentsch and Anzivino 2004;Laurent and Podhorna 2004;Shannon and Love 2004;Egerton et al 2005;Rodefer et al 2005).…”