“…[35] Acridine dyes can bind with photo damaged nucleic acids which have increasing interest as mutagens in micro-organisms. [36] The usefulness of acridines have led to the development of numerous methods of their synthesis by the three component Hantzsch condensation of aldehydes with β-diketones and ammonium acetate or appropriate primary amines. Many procedures describe the synthesis of acridinedione derivatives by cyclocondensation between dimedone and aldehyde and primary amine in the presence of heat in organic solvents with a varity of catalysts such as Fe 3 O 4 @B-MCM-41, [37] SO 4 2/TiO 2 NPs, [38] Scolecite, [39] Pd nanoparticle, [40] MNPsN-propyl-benzoguanamine-SO 3 H, [41] silica bonded N-propyl sulfamic acid [42] , CH 3 SO 3 H, [43] tetrabutylammonium hexatungstate, [44] nano TiO 2 , [45] SiO 2 /ZnCl 2 , [46] protic pyridinium ionic liquid, [47] CsCO 3 , [48] ceric ammonium nitrate, [49] organocatalysts, [50] Ni nanoparticles, [51] MgO, [52] thiamine hydrochloride, [53] SnO 2 , [54] La 2 O 3 /TFE (2,2,2-trifluoroethanol), [55] Cd(NO 3 ) 2 .4H 2 O.…”