3-(4-Chlorobenzoyl)-7-(N,N-dimethylamino)-1-phenylindolizine and 3-(2,4-dichlorobenzoyl)-7-(N,N-dimethylamino)-1-phenylindolizine

Abstract

In both of the title compounds, C(23)H(19)ClN(2)O, (I), and C(23)H(18)Cl(2)N(2)O, (II), the molecular packing is influenced by weak intermolecular C-H.O and C-H.pi interactions, but despite the chemical similarity of the compounds, the packing in (II) is entirely different from that observed in (I).

Dimethyl 7-(N,N-dimethylamino)-3-(2-methoxybenzoyl)indolizine-1,2-dicarboxylate

“…The bond lengths and bond angles in (I) are comparable with those in related structures (Hema et al, 2003(Hema et al, , 2004. The non-H atoms of (I) common to two related indolizine derivatives, dimethyl 3-benzoyl-7-(N,N-dimethylamino)indolizine-1,2-dicarboxylate and 3-(4-bromobenzoyl)-7-(N,N-dimethylamino)indolizine-1,2-dicarboxylate (Hema et al, 2003(Hema et al, , 2004, were superimposed on the corresponding atoms of these latter compounds and the r.m.s. deviations were found to be 1.2 and 0.86 Å , respectively.…”

Newly synthesized indolizine derivatives – antimicrobial and antimutagenic properties

“…Several polyhydroxylated indolizines have been proved to be promising inhibitors of glycosides (Hempel et al, 1993;Brandi et al, 1995). Thus, indolizine derivatives represent an important class of bioactive compounds with a wide range of applications such as potential central nervous system depressants, calcium entry blockers, cardiovascular agents, spectral sensitizers, biological markers and novel dyes (Gubin et al, 1992;Gupta et al, 2003;Sonnenschein et al, 2000;Hema et al, 2003). Other well-known pharmacological applications associated with this ring system are well documented in literature (Jørgensen et al, 2000;Wavefunction, 2006).…”

(3aR,4R,4aS,9aR)-4-Hydroxyperhydrofuro[2,3-f]indolizin-7(2H)-one

“…The synthesis of biologically active indolizine derivatives continues to attract the attention of organic chemists because of their importance as pharmaceutical drugs, for example as potential central nervous system depressants, calcium entry blockers, cardiovascular agents, spectral sensitizers and novel dyes (Gubin et al, 1992;Poty et al, 1994;Hema et al, 2003). Several polyhydroxylated indolizines are interesting as inhibitors of glycosides (Hempel et al, 1993;Brandi et al, 1995).…”