3,4-Dihydropyrimidin-2(1H)-one derivatives: Organocatalysed microwave assisted synthesis and evaluation of their antioxidant activity

A mini-review on Biginelli adducts with notable pharmacological properties

“…3 ) and 103 – 105 ( Fig. 7 ) were demonstrated to be as efficient as gallic acid in the scavenging of DPPH at 40 μg mL −1 as the IC 50 values for these adducts ranged from 2.1 to 5.0 μg mL −1 [46] .…”

Calcium, Barium and Strontium apatites: A new generation of catalysts in the Biginelli reaction

“…These compounds, also called "Biginelli compounds", have attracted attention as important structural motifs in medicinal chemistry because of their significant biological activities, such as antiviral, antimicrobial, antitumor, antibacterial, and anti-inflammatory properties [14,15]. Many of them are pharmacologically used as potent calcium channel blockers, antihypertensive agents, and neuropeptide antagonists [16].…”

Thermodynamic Properties of 6-Methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid Esters

“…The synthesis of esters was carried out at the Department of Organic Chemistry at Ivan Franko National University of Lviv according to the procedure described in [11]. The synthesis was carried out in a glass reactor loaded with corresponding aromatic aldehyde, urea, methyl or ethyl esters of acetoacetic acid in the presence of concentrated hydrochloric acid, in the medium of ethanol.…”