(3,4-Dihydroxy-phenylamino)-2-imidazoline (DPI), a new potent agonist at dopamine receptors mediating neuronal inhibition

Boudier, H. Struyker; Teppema, L.J.; Cools, Alexander R.; Rossum, Joris van

doi:10.1111/j.2042-7158.1975.tb10240.x

Cited by 45 publications

(2 citation statements)

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“…First, a doseeffect curve was made. Second, DPI was combined with the dopamine DA, antagonist ergometrine (Struyker Boudier et al, 1975;Cools et al, 1976). …”

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Evidence for a role of the shell of the nucleus accumbens in oral behavior of freely moving rats

et al. 1994

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Behavioraleffects of intra-accumbens administration of the dopamine DA, receptor agonist (3,4-dihydroxyphenylimino)-2-imidazoline (DPI) were studied in freely moving rats. Three distinct areas were examined: core, shell and "shore," namely, the border region of the core and shell. DPI (5 pg) administered into the shell, but not areas ventral to the shell, increased chewing, tongue protrusion, sniffing, and grooming; it also induced abnormal oral behavior, namely, largeamplitude chewing.A similar dose of DPI administered into the core did not affect any (peri-)oral behavior, except sniffing. Because of methodological constraints the receptor specificity of the DPI effects was studied in rats with cannulas directed at the shore. DPI (5.0-l 0.0 pg) administered into the shore increased oral behavior dose dependently; however, the dose-effect curve varied per distinct type of oral behavior. The dopamine DA, receptor antagonist ergometrine attenuated the effect of DPI on tremor, chewing, and sniffing frequencies.Taken together, the data show that the effects of DPI were DA, receptor specific. The idea that the nucleus accumbens is a homogeneous structure is disappearing. During the last 10 years differences have been found between core and shell with respect to anatomy (Zaborsky et al., 1985; Voorn et al., 1989; Heimer et al., 1991;Berendse et al., 1992;Zahm and Brog, 1992; and others), receptor density (Bardo and Hammer, 199 l), pharmacology (Deutch and Cameron, 1992), and electrophysiology (Pennartz et al., 1992). Still, with respect to behavior of freely moving rats, no studies on differences between core and shell have been performed. Therefore, the aim of this study was to analyze the role of different parts of the nucleus accumbens in modulating behavior. The nucleus accumbens modulates oral behavior in rats (Bordi et al., 1989;Cools, 1990;Koshikawa et al., 1990 Koshikawa et al., , 1991Prinssen et al., 1992; Koene et al., 1993). It has been found that intra-accumbens administration of the dopamine DA, receptor Received Mar. 11, 1993; revised July 1, 1993; accepted Aug. 26, 1993. We express our gratitude to Dick Heeren for his valuable support with programming, and to Luuk Lubbers for the learning of operation techniques. agonist (3,4-dihydroxyphenylimino)-2-imidazoline (DPI) increases oral behavior in rats (Cools, 1990). In cats, the same drug (DPI) has been found to induce abnormal oral movements, namely, orofacial dyskinesias (OFD), when administered into a well-delineated striatal subarea (Cools et al., 1976; Spooren et al., 199 1). Accordingly, DPI was considered to be a valid tool to study the putative, differential involvement of the core and shell of the nucleus accumbens in oral behavior of freely moving rats. In the present investigation the behavioral effects of DPI injections into the core were compared with those elicited by DPI injections into the shell. The outcome of this study shows that administration of DPI (5 Kg) into the shell, but not the core, increased and induced oral behaviors. How...

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“…First, a doseeffect curve was made. Second, DPI was combined with the dopamine DA, antagonist ergometrine (Struyker Boudier et al, 1975;Cools et al, 1976). …”

mentioning

confidence: 99%

Evidence for a role of the shell of the nucleus accumbens in oral behavior of freely moving rats

et al. 1994

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“…This e¤ect is locus-speciÞc, because it cannot be elicited from the medial part of the caudate nucleus (Spooren et al 1991a). This dopamine sensitive r-CRM area has been delineated on the basis of its insusceptibility to apomorphine and haloperidol, and its susceptibility to DPI, which is a potent agonist of the so-called DAi (IPSP-inducing) dopamine receptor subtype (Struyker Boudier et al 1975;), according to the original dopamine receptor subtype classiÞcation of . These DAi receptor subtypes are characterized by the following properties :…”

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Role of the retrorubral nucleus in striatally elicited orofacial dyskinesia in cats: effects of muscimol and bicuculline

Arts¹,

Bemelmans²,

Cools³

1998

Psychopharmacology

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Orofacial dyskinesia (OFD) is a disorder characterized by involuntary movements of the oral and facial muscles. OFD attacks can be elicited acutely in cats by local injections of dopaminergic agents into the anterodorsal part (r-CRM) of the caudate nucleus. Because the dopaminergic A8 cell group, being embedded in the retrorubral nucleus (RRN), gives rise to fibres which terminate in the r-CRM, two questions arose: (1) whether the A8 cell group forms part of the circuitry that directs and/or modulates OFD, and (2) whether GABA-ergic compounds in the RRN play a role in OFD, and if so, whether a pharmacological GABA-ergic intervention of the activity in the RRN modulates or mediates OFD. For this purpose, the activity of the RRN was manipulated with local injections of the GABA(A) agonist muscimol and antagonist bicuculline. These local injections into the RRN were subsequently combined with manipulations of dopamine transmission in the r-CRM with local injections of the selective DAi receptor agonist (3,4-dihydroxyphenylimino)-2-imidazoline. The present study shows that local injections of GABA-ergic compounds into the RRN do not elicit OFD attacks in cats, but can modulate oral behaviour elicited from the r-CRM. The latter effect is dose dependent and GABA-ergic specific.

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Dopamine receptors: Functions, subtypes and emerging concepts

Kaiser¹,

Jain²

1985

Medicinal Research Reviews

100

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(3,4-Dihydroxy-phenylamino)-2-imidazoline (DPI), a new potent agonist at dopamine receptors mediating neuronal inhibition

Cited by 45 publications

References 3 publications

Evidence for a role of the shell of the nucleus accumbens in oral behavior of freely moving rats

Evidence for a role of the shell of the nucleus accumbens in oral behavior of freely moving rats

Role of the retrorubral nucleus in striatally elicited orofacial dyskinesia in cats: effects of muscimol and bicuculline

Dopamine receptors: Functions, subtypes and emerging concepts

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