3,4-Dihydroxyphenyl 3,4,5-trimethoxybenzoate

Abstract

In the title compound, C16H16O7, the dihedral angle between the two benzene rings is 82.02 (7)°. The crystal structure is stabilized by inter­molecular O—H⋯O hydrogen bonds, which link the mol­ecules into a two-dimensional network.

1-[3-(Hydroxymethyl)phenyl]-3-phenylurea

“…Numerous potential tyrosinase inhibitors have been discovered from natural and synthetic sources, such as ascorbic acid (Kojima et al, 1995), kojic acid (Cabanes et al, 1994), arbutin (Casañola-Martin et al, 2006) and tropolone (Son et al, 2000). They contain aromatic, methoxy, hydroxyl (Hong et al, 2008;Lee et al, 2007), aldehyde (Yi et al, 2010), and amide (Choi et al, 2010) groups in their structure. Nevertheless, some of their individual activities are either not potent enough to be considered of practical use or not compatible with safety regulations for food and cosmetic additives.…”

N-(3,4-Difluorophenyl)-3,4,5-trimethoxybenzamide

“…For background to the development of potent inhibitory agents of tyrosinase and melanin formation as whitening agents, see: Cabanes et al (1994); Dawley & Flurkey (1993); Ha et al (2007); Hong et al (2008); Kwak et al (2010); ; Nerya et al (2003); Park et al (2010); Sung & Samyang Genex (2001); Yi et al (2009Yi et al ( , 2010.…”

“…Recently, a number of reports have focused on the development of new agents for the inhibition of tyrosinase. They contain aromatic, methoxy, hydroxyl (Hong et al, 2008;Lee et al, 2007), aldehyde (Yi et al, 2010), amide (Kwak et al, 2010), thiosemicarbazone (Yi et al, 2009) groups in their respective molecule structure. The application of natural products as a melanin synthesis inhibitors has also attracted interest (Park et al, 2010;Sung et al, 2001).…”

4-Hydroxyphenyl 4-fluorobenzoate

“…For general background to whitening agents, see: Ha et al (2007); Dawley et al (1993); Nerya et al (2003); Hong et al (2008); Lee et al (2007); Hussain et al (2003).…”

“…Most skin whitening agents currently on the market (Dawley et al, 1993;Nerya et al, 2003) are hydroquinone, ascorbic acid, kojic acid, arbutin, azealic acid, and glycyrrhetinic acid. They contain aromatic, methoxy, hydroxyl (Hong et al, 2008;Lee et al, 2007), or carbonyl functional groups in their structures, and act as a specific functional group to make the skin white by inhibiting the production of melanin. However, most skin whitening agents have some problems, due to toxicity, low stability of formulation and poor skin permeation.…”