3,4-Dimethoxyphenylethylamine in Schizophrenia?

Bourdillon, R.E.; Ridges, A. Pauline

doi:10.1016/b978-0-08-012039-3.50010-5

Cited by 7 publications

(1 citation statement)

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“…Disturbances in catecholamine metabolism have often been suggested to occur in schizophrenia (Bourdillon and Ridges 1970). However, the nature of the disturbance and its relationship to the disease process are unclear, since many other factors, unassociated with schizophrenia, may be responsible for the observed differences, and control of all of these has not been possible.…”

Section: Introductionmentioning

confidence: 99%

Monoamine Oxidase Activity: A Genetic Marker of Schizophrenia?

Owen

Ridges

Cookson

1974

Acta genet. med. gemellol.

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The results of pilot studies of the activities of platelet monoamine oxidase (MAO) and catechol-0-methyl transferase (COMT) in the blood of selected schizophrenics and the families of schizophrenics is presented.No statistically significant difference was found between the blood COMT levels of 21 control subjects and 26 schizophrenics, whereas the values found for platelet MAO activity were significantly lower for the schizophrenic group than for the control group.In one acutely disturbed first-admission schizophrenic the platelet MAO activity increased to a normal level in parallel with the clinical improvement, whereas in the relapsing schizophrenics the platelet MAO activity remained at its initial level although the clinical picture improved. No consistent findings with regard to the platelet MAO activity emerged from the study of 3 families having a history of schizophrenia.

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Section: Introductionmentioning

confidence: 99%