3,4-Methylenedioxypyrovalerone (MDPV): Chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online

Coppola, Maurizio; Mondola, Raffaella

doi:10.1016/j.toxlet.2011.10.002

Cited by 144 publications

(129 citation statements)

References 27 publications

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“…Because of that, mdpV readily crosses the blood-brain barrier and it can exert their powerful psychoactive effects (Coppola and Mondola, 2012;Kolanos et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

Untitled

2017

AgoraSalut

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“…Because of that, mdpV readily crosses the blood-brain barrier and it can exert their powerful psychoactive effects (Coppola and Mondola, 2012;Kolanos et al, 2013).…”

Section: Methodsmentioning

confidence: 99%

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2017

AgoraSalut

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“…Phase-1 metabolism, which was found in animal and in vitro studies include demthylation, followed by methylation, aromatic side chainhydroxylation and oxidation of the pyrrolidine to its corresponding lactam and the opening of the cycle to a carboxyl acid [13][14][15][16]. No data exist about the biological activity of these metabolites.…”

Section: 4´-dmarmentioning

confidence: 99%

Potential Drug Interactions Between cART and New Psychoactive Substances

Hentig¹

2016

J Antivir Antiretrovir

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“…A multiplicity of colorful brand names have been used (e.g., Cloud 9, Vanilla Sky, Ivory Wave, White Lightning) on packages for sale by gas stations, head shops, adult book stores, and Internet suppliers (1,5,6 ). These drugs are taken orally, intranasally, intravenously, or rectally and have highly addictive potential.…”

Section: Patient Follow-upmentioning

confidence: 99%

“…Randox Toxicology has recently marketed an immunoassay for cathinone derivatives (5 ), and Ameritox has developed a mass spectrometry test (6 ). These tests may be useful for emergency physicians and for law enforcement, especially in areas with a high prevalence of bath salt use.…”

Section: Clinical Case Study Author Contributions: All Authors Confirmentioning

confidence: 99%

Violent Behavior and Hallucination in a 32-Year-Old Patient

Truscott¹,

Crittenden

Shaw

et al. 2013

Clinical Chemistry

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CASEA 32-year-old white male was brought to the emergency department by police after a sudden, dangerous outburst. He had allegedly assaulted his girlfriend and attempted to run her over with his car. Subsequently, the patient reportedly stole and/or damaged numerous other motor vehicles. Several security and law enforcement officers were required to subdue the patient and bring an end to his hallucination-driven rampage, which lasted about 2 hours. The patient's medical history included chronic back pain, hypertension, and a long history of substance abuse, including alcohol, tobacco, and marijuana. A physical examination revealed the following: blood pressure, 132/88 mmHg; heart rate, 135 beats/min; respiratory rate, 18/min; body temperature, 98.7°F; oxygen saturation, 98% on room air. He was markedly anxious, distressed, and sweating profusely. His pupils were normal in size and reactive to light. The patient had mild abrasions on his hands, arms, and shoulders, but he had no severe injuries. He progressively became more agitated in the emergency department and required 10 mg ziprasidone intramuscularly and 2 mg lorazepam intravenously for sedation. Intoxication with psychoactive substances was suspected; however, the results of routine screening tests of serum and urine samples were negative for alcohols, amphetamines, cocaine, and opioids.

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3,4-Methylenedioxypyrovalerone (MDPV): Chemistry, pharmacology and toxicology of a new designer drug of abuse marketed online

Cited by 144 publications

References 27 publications

Untitled

Untitled

Potential Drug Interactions Between cART and New Psychoactive Substances

Violent Behavior and Hallucination in a 32-Year-Old Patient

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