3:45 PM Abstract No. 106 Comparing solid embolic devices for the embolization of pulmonary arteriovenous malformations: an update

Abstract

assessment of the corresponding vessels in human fundal sections from normal obese human patients. Materials: Four healthy juvenile swine underwent bariatric arterial using 50-μm spherical embolics and the animals were humanely euthanized after four weeks for pathological analysis. The stomachs were harvested and representative fundal sections were collected and processed for routine H&E histology. Concurrently, gastric fundal remnants from patients who had undergone gastric bypass were obtained (n ¼ 18) and representative sections were fixed in formalin and processed for routine H&E histology. In both cases, slides were scanned at 20X magnification using a NanoZoomerDigital Slide Scanner (Hamamatsu Corporation Japan). Vessels in the region where embolic deposition was identified in swine were measured and averaged using Halo software (Indica Labs, Corrales, New Mexico) and verified by a board-certified pathologist. Arteries in a similar histologic region in the submucosa were then measured in the human fundal sections, and also verified by a board-certified pathologist. Results: Presence of 50-micron embolics was confirmed in the fundus in all experimental animals with specific deposition in arteries located in the luminal half of the submucosal layer. Average blood vessels in this region measured 49.3 ± 30.2 microns (n ¼ 27) in the experimental swine. The average vessel size in this same region in the human fundal sections was 39.9 ± 29.9 microns (n ¼ 337). Conclusions: Based on this histopathologic analysis, a bead measuring closer to 50-80 microns could theoretically be used in future human bariatric embolization trials to mimic the weight loss and safety profile observed in the swine model.