3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from <i>Chrysanthemum indicum</i> Extract Show Potential for the Treatment of Alzheimer’s Disease

Wu, Taizong; Jiang, Cheng; Morris‐Natschke, Susan L.; Miao, Hui; Gu, Lian‐Quan; Xu, Jing; Lee, Kuo Hsiung̀; Gu, Qiong

doi:10.1021/acs.jnatprod.5b00156

Cited by 38 publications

(29 citation statements)

References 20 publications

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“…47 . It is noteworthy to mention here that, 3,5-diarylpyrazole analogues become one Wu et al, 2015 of the best alternatives to bioactive compounds, as it exhibit several advantages like A² aggregation, neuroprotective activity which are useful in Alzheimer's disease treatment 48 54 . The supercritical-carbon dioxide fluid extract from Chrysanthemum indicum Wu et al, 2014 Linne plays a vital role against lipopolysaccharide-induced acute lung injury (ALI) in mice.…”

Section: Key Findings Referencementioning

confidence: 99%

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

Chae¹

2016

Biosci., Biotech. Res. Asia

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The Chrysanthemum is a well-known traditional Chinese medicinal herb which has been used as a drug for thousands of years. From the detailed literature survey it is determined that the dried flowers of Chrysanthemum contain organic groups such as alkanes, flavonoids, terpinoids, unsaturated fatty acids and polysaccharides which belongs to Secondary constituents in Phytochemicals classification. The knowledge and analysis of bioactive compounds present in the Chrysanthemums can be used for next generation drug development process. The developments of new drugs against diabetes and prostate cancer have become global concern. Hence the present study leads to identify the new strategies which are needed to develop multi-functional drugs against various human diseases using Chrysanthemum plant. Owing to antifungal, antibacterial and anti-inflammation activities, Chrysanthemum have much attention in the field of biomolecules research. In general Phytochemicals can be classified as primary and secondary constituents. One can understand the fascinating properties of biological compounds via phytochemical analysis which are present in the plants. Therefore, the present study gives a better understanding of phytochemical properties of Chrysanthemum and new foundations for the production of non-toxic and eco-friendly drugs of today and the future.

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Section: Key Findings Referencementioning

confidence: 99%

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

Chae¹

2016

Biosci., Biotech. Res. Asia

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“…) . A natural extract of the flowers of Chrysanthemum indicum was also diversified using this strategy, resulting in the generation of four new 3,5‐diarylpyrazole analogues ( 128 – 131 ) . All four compounds showed moderate to potent activity against amyloid‐ β ‐induced aggregation, indicating their potential for treating Alzheimer's disease …”

Section: Biological Synthetic and Semisynthetic Approachesmentioning

confidence: 99%

Strategies to diversify natural products for drug discovery

Lou

2017

Medicinal Research Reviews

222

130

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Natural product libraries contain specialized metabolites derived from plants, animals, and microorganisms that play a pivotal role in drug discovery due to their immense structural diversity and wide variety of biological activities. The strategies to greatly extend natural product scaffolds through available biological and chemical approaches offer unique opportunities to access a new series of natural product analogues, enabling the construction of diverse natural product-like libraries. The affordability of these structurally diverse molecules has been a crucial step in accelerating drug discovery. This review provides an overview of various approaches to exploit the diversity of compounds for natural product-based drug development, drawing upon a series of examples to illustrate each strategy.

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“…The subsequent isolation of each compound produced from such reactions affords a diverse natural‐product‐like library of new molecular scaffolds. There have also been some reports on similar methods that chemically convert natural extracts . However, we defined diversity‐enhanced extracts as natural extracts formed by multiple diversity‐generating reactions that not only convert functional groups, but also form new carbon–carbon bonds and modify the molecular scaffolds similarly to diversity‐oriented synthesis.…”

Section: Introductionmentioning

confidence: 99%

“…There have also been some reports on similar methodst hat chemically convert natural extracts. [6][7][8][9][10][11] However, we defined diversity-enhanced extracts as natural extracts formed by multiple diversity-generating reactions that not only convert functional groups, buta lso form new carbon-carbon bonds and modify the moleculars caffolds similarly to diversity-oriented synthesis.…”

Section: Introductionmentioning

confidence: 99%

Construction of a Meroterpenoid‐Like Compounds Library Based on Diversity‐Enhanced Extracts

Kikuchi

Kawai

Nakashiro

et al. 2018

Chemistry A European J

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The structural diversity of natural products and their derivatives have long contributed to the development of new drugs. However, the difficulty in obtaining compounds bearing skeletally novel structures has recently led to a decline of pharmaceutical research into natural products. This paper reports the construction of a meroterpenoid‐like library containing 25 compounds with diverse molecular scaffolds obtained from diversity‐enhanced extracts. This method constitutes an approach for increasing the chemical diversity of natural‐product‐like compounds by combining natural product chemistry and diversity‐oriented synthesis. Extensive pharmacological screening of the library revealed promising compounds for anti‐osteoporotic and anti‐lymphoma/leukemia drugs. This result indicates that the use of diversity‐enhanced extracts is an effective methodology for producing chemical libraries for the purpose of drug discovery.

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3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer’s Disease

Cited by 38 publications

References 20 publications

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

An Up-to-Date Review of Phytochemicals and Biological Activities in Chrysanthemum spp

Strategies to diversify natural products for drug discovery

Construction of a Meroterpenoid‐Like Compounds Library Based on Diversity‐Enhanced Extracts

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