3-Arylidene-2-Oxindoles as Quinone Reductase Ii Inhibitors

Abstract

Quinone reductase II (QR2) is an enzyme which exibits antioxidant, neuroprotective and chronobiotic properties. Previously we reported that 3-substituted-2-oindoles posess an affinity towards this molecular target and act as potential anti-glaucoma agents [1,2]. A number of novel compounds with 3-arylidene-2-oxindole scaffold were synthesized [3].