3-(Bromomethyl)-2-chloro-4-(methylsulfonyl)- benzoic acid: a new cause of sensitiser induced occupational asthma, rhinitis and urticaria

Suojalehto, Hille; Karvala, Kirsi; Ahonen, Saana; Ylinen, Katriina; Airaksinen, Liisa; Suuronen, Katri; Lindström, Irmeli

doi:10.1136/oemed-2017-104505

Cited by 7 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, it facilitates comparison of epidemiological results. Recent population-based studies and clinical trials utilise one of the aforementioned testing methods each: Sovij€ arvi [30][31][32][33][34][35][36][37], Malmberg [38][39][40][41] or Nieminen [14,[42][43][44]; the reference table may serve the purpose of offering comparisons in these example studies and others, or in future studies. Nowadays, the supply of histamine as a challenge test substance is very limited, therefore, a comparison to other challenge methods was also needed.…”

Section: Utilitymentioning

confidence: 99%

Measurement of bronchial hyperreactivity: comparison of three Nordic dosimetric methods

Lassmann-Klee

Sundblad

Malmberg

et al. 2020

Scandinavian Journal of Clinical and Laboratory Investigation

View full text Add to dashboard Cite

Clinical testing of bronchial hyperreactivity (BHR) provides valuable information in asthma diagnostics. Nevertheless, the test results depend to a great extent on the testing procedure: test substance, apparatus and protocol. In Nordic countries, three protocols predominate in the testing field: Per Malmberg, Nieminen and Sovij€ arvi methods. However, knowledge of their equivalence is limited. We aimed to find equivalent provocative doses (PD) to obtain similar bronchoconstrictive responses for the three protocols. We recruited 31 patients with suspected asthma and health care workers and performed BHR testing with methacholine according to Malmberg and Nieminen methods, and with histamine according to Sovij€ arvi. We obtained the individual response-dose slopes for each method and predicted equivalent PD values. Applying a mixed-model, we found significant differences in the mean (standard error of mean) response-dose (forced expiratory volume in one second (FEV 1 )%/mg): Sovij€ arvi 7.2 (1.5), Nieminen 13.8 (4.2) and Malmberg 26 (7.3). We found that the earlier reported cutpoint values for moderate BHR and marked BHR between the Sovij€ arvi (PD 15 ) and Nieminen (PD 20 ) methods were similar, but with the Malmberg method a significant bronchoconstrictive reaction was measured with lower PD 20 values. We obtained a relationship between slope values and PD (mg) between different methods, useful in epidemiological research and clinical practice.

show abstract

Section: Utilitymentioning

confidence: 99%

Measurement of bronchial hyperreactivity: comparison of three Nordic dosimetric methods

Lassmann-Klee

Sundblad

Malmberg

et al. 2020

Scandinavian Journal of Clinical and Laboratory Investigation

View full text Add to dashboard Cite

show abstract

“…Reviews of compensated claims for work-related asthma and clinic reviews have suggested a reduction over the past few years in rates of recognized occupational asthma in several jurisdictions, such as in Canada, France and England,234 possibly due to preventive measures. However, new causes of occupational asthma continue to be reported 5678. In addition, general population studies continue to suggest relatively high rates of work-related asthma accounting from 15% of adult asthmatics in a US survey,910 up to 33% of adult asthmatics who reported work-related aggravation of asthma in a British postal survey (though the overall response rate was low at 13%) 11.…”

Section: Introductionmentioning

confidence: 99%

Update on the Management of Occupational Asthma and Work-Exacerbated Asthma

Lau

Tarlo

2019

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

Work-related asthma is the most common occupational lung disease encountered in clinical practice. In adult asthmatics, work-relatedness can account for 15%–33% of cases, but delays in diagnosis remain common and lead to worse outcomes. Accurate diagnosis of asthma is the first step to managing occupational asthma, which can be sensitizer-induced or irritant-induced asthma. While latency has traditionally been recognized as a hallmark of sensitizer-induced asthma and rapid-onset a defining feature of irritant-induced asthma (as in Reactive Airway Dysfunction Syndrome), there is epidemiological evidence for irritant-induced asthma with latency from chronic moderate exposure. Diagnostic testing while the patient is still in the workplace significantly improves sensitivity. While specific inhalational challenges remain the gold-standard for the diagnosis of occupational asthma, they are not available outside of specialized centers. Commonly available tests including bronchoprovocation challenges and peak flow monitoring are important tools for practicing clinicians. Management of sensitizer-induced occupational asthma is notable for the central importance of removal from the causative agent: ideally, removal of the culprit agent; but if not feasible, this may require changes in the work process or ultimately, removal of the worker from the workplace. While workers' compensation programs may reduce income loss, these are not universal and there can be significant socio-economic impact from work-related asthma. Primary prevention remains the preferred method of reducing the burden of occupational asthma, which may include modification to work processes, better worker education and substitution of sensitizing agents from the workplace with safer compounds.

show abstract

“…O mecanismo fisiopatológico envolvido na indução de asma ocupacional por agentes de baixo peso molecular permanece amplamente desconhecido (MAESTRELLI et al, 2009). Sabe-se que na maioria dos casos o mecanismo é IgE independente, como o caso do epoxi amina (VANDENPLAS et al, 2017), contudo, alguns dos agentes de baixo peso também induzem asma com mecanismo IgE dependente, como é o caso do 3-Bromo Metil-2-cloro-4-(metil Sulfonil) -ácido benzoico (SUOJALEHTO et al, 2018).…”

Section: Asma Relacionada Ao Trabalhounclassified

“…Exemplos de trabalhadores com elevado risco de desenvolvimento de asma induzida pela exposição a irritantes químicos incluem, profissionais de área da saúde, principalmente fisioterapeuta respiratório, enfermeiros e terapeutas ocupacionais (ARIF; DELCOS, 2012); pessoal de serviço de limpeza (ARIF et al, 2003; ZOCK; VIZCAYA; LE MOUAL, 2010); trabalhadores envolvidos na fabricação de produtos químicos (SUOJALEHTO et al, 2018); pessoas que trabalham com revestimento contendo epóxi (VANDENPLAS et al, 2017). O primeiro passo para o diagnóstico de asma relacionada ao trabalho é a confirmação clínica de que o paciente realmente tem asma.…”

Section: Asma Relacionada Ao Trabalhounclassified

Estudo comparativo da sensibilização alérgica a animais de laboratório e sensibilização alérgica comum: efeitos sobre sintomas cutâneos, rinite, asma e hiperreatividade brônquica avaliada pelo teste de broncoprovocação com manitol

Simoneti¹

View full text Add to dashboard Cite

show abstract

3-(Bromomethyl)-2-chloro-4-(methylsulfonyl)- benzoic acid: a new cause of sensitiser induced occupational asthma, rhinitis and urticaria

Cited by 7 publications

References 25 publications

Measurement of bronchial hyperreactivity: comparison of three Nordic dosimetric methods

Measurement of bronchial hyperreactivity: comparison of three Nordic dosimetric methods

Update on the Management of Occupational Asthma and Work-Exacerbated Asthma

Estudo comparativo da sensibilização alérgica a animais de laboratório e sensibilização alérgica comum: efeitos sobre sintomas cutâneos, rinite, asma e hiperreatividade brônquica avaliada pelo teste de broncoprovocação com manitol

Contact Info

Product

Resources

About