[(3-Chlorobenzamido)methyl]triethylammonium Chloride

Abstract

We report the synthesis of [(3-chlorobenzamido)methyl]triethylammonium chloride in a reaction of N-(chloromethyl)-3-chlorobenzamide and triethylamine in dry acetone. The structure of the newly synthesized compound was characterized with 1H-NMR, 13C-NMR, FTIR and Mass spectroscopy.

Synthesis, physicochemical characterization and antibacterial activity of novel (benzoylamino)methyl derivatives of quinolones

“…NOR (1), CIPRO (2) and PI-PEM (3) were purchased from Fluka (SigmaAldrich ChemieGmbh Munich, Germany). [(Benzoylamino) methyl]triethylammonium salts 4a-d were prepared as [(3-chlorobenzoylamino) methyl] triethylammonium chloride, as reported in BreznicaSelmani et al [19].…”

“…The advantages of the (benzoylamino)methylation procedure used in the study included convenient conditions for the synthesis, fast proceeding of the reaction, relatively uncomplicated isolation and high yields of the products (72-98%). Also, the (benzoylamino) methylation regents were prepared in relatively high yields (70-80%) and used without purification, with spectroscopic specification [19]. Preparation of the NOR derivatives 5a-e proceeded by stirring a mixture of NOR (1) (1.0 equivalent) and [(benzoylamino)methyl]triethylammonium salts 4a-d (1.5 equivalents) in dimethyl sulfoxide (DMSO) using triethylamine (Et3N) as a base, resulting in products with high yields, 82.0% to 96.4%.…”